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Middle ear adenoma with uncommon presentation and literature review
  1. Lin Wang1,
  2. Nengtai Ouyang2,
  3. Hai Xia Guo2,
  4. Qing-yu Liu2
  1. 1 Department of Pathology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China
  2. 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China
  1. Correspondence to Professor Lin Wang, gzdwanglin{at}


Middle ear adenoma (MEA) is a rare benign tumour. Here we report a case of MEA in a 39-year-old man with hearing loss. Some significant histopathological features of MEA and neuroendocrine differentiation identified by immunohistochemistry are described. The tumour showed remarkable and rare degenerative histological characteristics. There were a few tumour cells which were covered by degenerated tissue. Consequently, following frozen biopsy, the tumour was misdiagnosed as chronic ear inflammation. No recurrence was seen in this patient after 45 months of follow-up; regular clinical and radiological follow-up is necessary since recurrence is possible. A literature review for MEA is presented and this type of tumour is discussed clinically, microscopically and immunohistochemically. The differential diagnosis and associated treatment are described.

  • Ear, nose and throat/otolaryngology
  • Head and neck cancer
  • Pathology
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  • Contributors LW designed the study and wrote the manuscript; NTO, HX Guo and Q-YL were involved in editing the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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