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CASE REPORT
Haemolytic anaemia after nitrofurantoin treatment in a pregnant woman with G6PD deficiency
  1. Lidewij van de Mheen1,
  2. Simone M Smits2,
  3. Wim E Terpstra3,
  4. Anja Leyte2,
  5. Dick J Bekedam1,
  6. Eline S A van den Akker1
  1. 1Department of Obstetrics & Gynecology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
  2. 2Department of Clinical Chemistry, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
  3. 3Department of Hematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
  1. Correspondence to Lidewij van de Mheen, lidewijvandemheen{at}gmail.com

Summary

We present a normotensive, pregnant woman with severe haemolytic anaemia in the third trimester of pregnancy. Owing to normal platelet count diagnoses other than HELLP syndrome were considered and investigated. The patient was treated with nitrofurantoin 3 weeks before presentation and she turned out to have a deficiency of glucose-6-phosphate dehydrogenase. After treatment with blood transfusion, vitamin B12 and folic acid the patient recovered completely. Caesarean delivery was performed because of maternal hypertension and fetal distress at 33 weeks’ gestation.

https://doi.org/10.1136/bcr-2013-010087

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