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Unusual association of diseases/symptoms
Bone marrow fibrosis and metastatic prostate adenocarcinoma
  1. Abhishek Avinash Mangaonkar1,
  2. Hemant R Gupta2,
  3. Bhavin M Bera1,
  4. Shahid Barmare3
  1. 1Department of Medicine, Grant Medical College & Sir J.J. Group of Hospitals, Mumbai, Maharashtra, India
  2. 2Department of Medicine, Grant Medical College, Mumbai, Maharashtra, India
  3. 3Department of Medicine, Rajawadi Hospital, Mumbai, Maharashtra, India
  1. Correspondence to Dr Abhishek Avinash Mangaonkar, dr.abhishekmangaonkar{at}


A 52-year-old man presented to the outpatient department with breathlessness and generalised weakness since 2 months. He was found to have anaemia and thrombocytopenia. A complete haematological workup failed to point towards a definite aetiology. Bone marrow biopsy revealed fibrosis with predominantly collagen fibres. An elevated prostate-specific antigen level and CT scan of the abdomen and pelvis suggested prostate carcinoma, which prompted a transrectal ultrasound-guided biopsy, revealing a poorly differentiated adenocarcinoma of the prostate.

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