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Case Reports: Rare disease
Intraoral myeloid sarcoma presenting as toothache and gingival mass
  1. Ephrem Sedeta1,
  2. Akriti Pokhrel1,
  3. Kiron Nair2 and
  4. Vladimir Gotlieb2
  1. 1Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA
  2. 2Division of Hematology and Medical Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA
  1. Correspondence to Dr Ephrem Sedeta; ephremsedeta{at}gmail.com

Abstract

A female patient in her 70s with a medical history of myelodysplastic neoplasm presented to the outpatient department with a 4-month history of toothache, painful gingival swelling and loose teeth that required extractions. Intraoral examination revealed a swelling in the lower anterior portion of the mandible, which displaced her teeth. Incisional biopsy of the gingival lesion revealed dense aggregates of atypical round cells which stained positive for CD43, CD45, CD33 and myeloperoxidase, consistent with myeloid sarcoma. Subsequent bone marrow biopsy displayed hypercellular marrow with immature myeloid elements and 21% myeloblasts by flow cytometry, compatible with diagnosis of acute myeloid leukaemia (AML). The patient initially went into remission after treatment but later died of AML relapse after 18 months.

  • Malignant and Benign haematology
  • Malignant disease and immunosuppression

https://doi.org/10.1136/bcr-2022-251452

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    Footnotes

    • Twitter @Ephrem Sedeta

    • Contributors ES was involved in gathering medical records, drafting the case report and literature search, and referencing. VG and KN conceived the idea of writing the case report and managed the patient. AP reviewed the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.