Article Text
Abstract
Hepatopulmonary syndrome (HPS) is characterised by the development of intrapulmonary arteriovenous blood shunts and vascular dilatation with consequent hypoxaemia, usually in the context of end-stage liver disease (ESLD). The estimated incidence of HPS in ESLD has been reported to be 13%–47%. Chronic liver disease has been described in patients with hypothalamic–pituitary dysfunction, mainly in the form of non-alcoholic fatty liver disease due to metabolic syndrome, with occasional progression to cirrhosis. We report a challenging case of a 27-year-old man with a background of hypopituitarism with no known liver disease who presented with progressive dyspnoea and hypoxaemia and was eventually diagnosed with severe HPS.
- pituitary disorders
- cirrhosis
- pulmonary hypertension
- transplantation
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Footnotes
Twitter @EmanIbr02688658
Contributors EIA: Consenting, conception and design, acquisition of data and references, writing up draft and a member of the management team. YS: Collecting data and investigations results and writing up part of the draft. SK: Conception and design and revising the draft, with final approval of the version for publication. PB: Conception and design, revising the draft with final approval of the version for publication and senior member of the management team. GT: Conception and design, revising the draft with final approval of the version for publication and senior member of the management team.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.