[HTML][HTML] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent …

S Maruyama, R Shibata, R Kikuchi, Y Izumiya… - Journal of Biological …, 2012 - ASBMB
Obesity-related diseases are associated with vascular dysfunction and impaired
revascularization. Omentin is a fat-derived secreted protein, which is down-regulated in …

Sirt7 contributes to myocardial tissue repair by maintaining transforming growth factor-β signaling pathway

S Araki, Y Izumiya, T Rokutanda, A Ianni, S Hanatani… - Circulation, 2015 - Am Heart Assoc
Background—Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes
oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic …

Growth differentiation factor-15 is a useful prognostic marker in patients with heart failure with preserved ejection fraction

Y Izumiya, S Hanatani, Y Kimura, S Takashio… - Canadian Journal of …, 2014 - Elsevier
Background Circulating growth differentiation factor 15 (GDF-15) levels correlate with heart
mass and fibrosis; however, little is known about its value in predicting the prognosis of …

Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease

S Hanatani, Y Izumiya, S Araki… - Journal of the …, 2014 - journals.lww.com
Muscle wasting is frequently observed in patients with kidney disease, and low muscle
strength is associated with poor outcomes in these patients. However, little is known about …

[HTML][HTML] Chronic C-type natriuretic peptide infusion attenuates angiotensin II-induced myocardial superoxide production and cardiac remodeling

Y Izumiya, S Araki, H Usuku, T Rokutanda… - International Journal of …, 2012 - hindawi.com
Myocardial oxidative stress and inflammation are key mechanisms in cardiovascular
remodeling. C-type natriuretic peptide (CNP) is an endothelium-derived cardioprotective …

Akt1–mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction

S Araki, Y Izumiya, S Hanatani, T Rokutanda… - Circulation: Heart …, 2012 - Am Heart Assoc
Background—It is appreciated that aerobic endurance exercise can attenuate unfavorable
myocardial remodeling following myocardial infarction. In contrast, little is known about the …

Passive exercise using whole-body periodic acceleration enhances blood supply to ischemic hindlimb

T Rokutanda, Y Izumiya, M Miura… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—Whole-body periodic acceleration (WBPA) has been developed as a passive
exercise technique to improve endothelial function by increasing shear stress through …

Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction

S Hanatani, Y Izumiya, S Takashio, Y Kimura… - Circulation …, 2014 - jstage.jst.go.jp
Background: Thrombospondin-2 (TSP-2) is a matricellular protein found in human serum.
Deletion of TSP-2 causes age-dependent dilated cardiomyopathy. We hypothesized that …

Growth differentiation factor 15 can distinguish between hypertrophic cardiomyopathy and hypertensive hearts

S Hanatani, Y Izumiya, S Takashio, S Kojima… - Heart and Vessels, 2014 - Springer
To distinguish hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular
hypertrophy (H-LVH) based on a morphological examination is often challenging. Growth …

Simultaneous pressure recording in mid-ventricular obstructive hypertrophic cardiomyopathy

Y Hanaoka, I Misumi, T Rokutanda, R Akahoshi… - Internal …, 2012 - jstage.jst.go.jp
A 70-year-old man was diagnosed with mid-ventricular obstructive hypertrophic
cardiomyopathy (MVOHCM) with apical aneurysm and paradoxic jet flow. At cardiac …