Shear stress and plaque development

SS Dhawan, RP Avati Nanjundappa… - Expert review of …, 2010 - Taylor & Francis
Although traditional cardiovascular risk factors 'prime the soil'for atherogenesis systemically,
atherosclerosis primarily occurs in a site-specific manner with a predilection towards the …

Rheumatoid arthritis and cardiovascular disease

SS Dhawan, AA Quyyumi - Current atherosclerosis reports, 2008 - Springer
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease affecting
approximately 1% of the adult general population. Cardiovascular disease is recognized as …

Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery …

H Samady, P Eshtehardi, MC McDaniel, J Suo… - Circulation, 2011 - Am Heart Assoc
Background Experimental studies suggest that low wall shear stress (WSS) promotes
plaque development and high WSS is associated with plaque destabilization. We …

Association of coronary wall shear stress with atherosclerotic plaque burden, composition, and distribution in patients with coronary artery disease

P Eshtehardi, MC McDaniel, J Suo… - Journal of the …, 2012 - Am Heart Assoc
Background Extremes of wall shear stress (WSS) have been associated with plaque
progression and transformation, which has raised interest in the clinical assessment of WSS …

Effect of inlet velocity profiles on patient-specific computational fluid dynamics simulations of the carotid bifurcation

IC Campbell, J Ries, SS Dhawan, AA Quyyumi… - 2012 - asmedigitalcollection.asme.org
Patient-specific computational fluid dynamics (CFD) is a powerful tool for researching the
role of blood flow in disease processes. Modern clinical imaging technology such as MRI …

Effect of intensive atorvastatin therapy on coronary atherosclerosis progression, composition, arterial remodeling, and microvascular function.

P Eshtehardi, MC McDaniel, SS Dhawan… - The Journal of …, 2012 - europepmc.org
Background There is a discrepancy between the marked reduction in adverse events with
statins and their modest effect on atheroma regression. We hypothesized that, in a Western …

Coronary microvascular dysfunction is associated with higher frequency of thin-cap fibroatheroma

SS Dhawan, MT Corban, RA Nanjundappa… - Atherosclerosis, 2012 - Elsevier
OBJECTIVE: Both coronary microvascular dysfunction and epicardial plaque vulnerability
have been associated with adverse cardiovascular outcomes. However, whether …

The role of plasma aminothiols in the prediction of coronary microvascular dysfunction and plaque vulnerability

SS Dhawan, P Eshtehardi, MC McDaniel, LV Fike… - Atherosclerosis, 2011 - Elsevier
BACKGROUND: Although oxidative stress is considered a key pathogenic step in mediating
vascular dysfunction and atherosclerosis development, their association has not been …

Effect of angiotensin II type I receptor blockade with valsartan on carotid artery atherosclerosis: a double blind randomized clinical trial comparing valsartan and …

R Ramadan, SS Dhawan, JNG Binongo… - American heart …, 2016 - Elsevier
Background Progression of atherosclerosis is associated with a greater risk for adverse
outcomes. Angiotensin II plays a key role in the pathogenesis and progression of …

Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease

R Ramadan, SS Dhawan, H Syed… - Journal of …, 2014 - journals.lww.com
Background: Traditional cardiovascular risk factors lead to endothelial injury and activation
of leukocytes and platelets that initiate and propagate atherosclerosis. We proposed that …