Human CD8+ memory-and effector-type T cells are poorly defined. We show here that, next
to a naive compartment, two discrete primed subpopulations can be found within the …

CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are
commonly used for the treatment of B cell malignancies and autoantibody-mediated …

The interaction between the TNF receptor family member CD27 and its ligand CD70
provides a costimulatory signal for T cell expansion. Normally, tightly regulated expression …

It has been proposed that HIV-1, in addition to directly infecting and killing CD4+ T cells,
causes T cell dysfunction and T cell loss by chronic immune activation. We analyzed the …

A 3-month-old girl, the first child of consanguineous parents with a family history of
unexplained febrile episodes including a death from infection of the eldest brother of the …

During immunosuppression, cytomegalovirus (CMV) can reactivate and cause serious
clinical problems. Normally, abundant virus replication is suppressed by immune effector …

The absence of the TNF-receptor family member CD27 marks the stable acquisition of
cytolytic effector functions by both CD4+ and CD8+ T cells. We found that the majority of …

Viral infections may cause serious disease unless the adaptive immune system is able to
clear the viral agents through its effector arms. Recent identification and functional …

We recently showed that circulating human CD8+ effector cells have a CD45RA+ CD27–
membrane phenotype. In itself this phenotype appeared to pose a paradox: CD45RA, a …

Two prototypic types of virus-specific CD8+ T cells can be found in latently infected
individuals: CD45R0+ CD27+ CCR7− effector-memory, and CD45RA+ CD27− CCR7 …