PURPOSE: Transanal hemorrhoidal dearterialization consists of a Doppler-guided ligation
of the distal branches of the rectal arteries. The aim of this review is to assess the current …

Ideal surgical treatment for anal fistula should aim to eradicate sepsis and promote healing
of the tract, whilst preserving the sphincters and the mechanism of continence. For the …

Background Several studies concluded that mechanical bowel preparation (MBP) does not
confer any advantage on reducing the anastomotic leak rate or wound infections. The aim of …

Objectives To assess the long-term results of stapled hemorrhoidopexy (SH) compared with
conventional hemorrhoidectomy (CH) and to define the role of SH in the treatment of …

Background A proportion of patients with chronic anal fissure have persistent symptoms and
pathology despite optimum conservative therapies. Lateral anal sphincterotomy, the …

BACKGROUND: Optimal surgical intervention for low-grade haemorrhoids is unknown.
Rubber band ligation (RBL) is probably the most common intervention. Haemorrhoidal …

Abstract Ubiquitin‐conjugating enzyme 9 (Ubc9) is required for sumoylation and is
overexpressed in several malignancies, but its expression in hepatocellular carcinoma …

Abstract Methionine adenosyltransferase 2B (MAT2B) encodes for two variant proteins (V1
and V2) that promote cell growth. Using in‐solution proteomics, GIT1 (G Protein Coupled …

Methionine adenosyltransferase (MAT) is an essential enzyme that is responsible for the
biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and precursor of …

Aim There is considerable heterogeneity in outcomes in studies reporting on the treatment of
haemorrhoidal disease (HD). The aim of this study was to develop a Core Outcome Set …