Background: The metabolic syndrome is associated with low-grade inflammation. It has
been suggested that proinflammatory cytokines and low-grade systemic inflammation …

PURPOSE: Colonoscopy can be painful for patients and difficult for colonoscopists;
however, it is hard to predict how painful or difficult the examination will be. This study was …

PURPOSE: Decreased bone mineral density defines osteoporosis according to the World
Health Organization and is an important predictor of future fractures. The use of several …

PURPOSE The administration of sedative drugs at colonoscopy has its drawbacks, such as
increasing the rate of complications and the cost. There are a number of potential …

Purpose Real‐world data from large administrative claims databases in Japan have recently
become available, but limited evidence exists to support their validity. VALIDATE‐J validated …

Objective Accelerated atherosclerosis is an important cause of morbidity and mortality in
patients with systemic lupus erythematosus (SLE). Altered coronary microvascular function …

BACKGROUND: Histamine may play an important role in bone turnover. The data regarding
histamine 1 receptor antagonist (H1RA), histamine 2 receptor antagonist (H2RA), and bone …

Objective Altered pain sensitivity may affect the outcome of appendicitis in patients with
schizophrenia. We aimed to compare the prevalence of perforation in appendicitis between …

A 66-year-old woman with a history of interstitial lung disease presented with a 3-month
history of dropped head syndrome (DHS), followed by camptocormia and extremity …

Objectives Healthy user bias arises when users of preventive medications such as lipid-
lowering drugs (LLDs), hormone replacement therapy and antihypertensive (AH) …