Zinc: the brain's dark horse

BKY Bitanihirwe, MG Cunningham - Synapse, 2009 - Wiley Online Library
Zinc is a life‐sustaining trace element, serving structural, catalytic, and regulatory roles in
cellular biology. It is required for normal mammalian brain development and physiology …

Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology

FM Benes, JB Taylor, MC Cunningham - Cerebral Cortex, 2000 - academic.oup.com
A variety of observations have suggested that the dopamine and serotonin systems may
play a role in the pathophysiology and treatment of major mental disorders of childhood …

Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

L Zimmerman, U Lendahl, M Cunningham, R McKay… - Neuron, 1994 - cell.com
Changes in intermediate filament gene expression occur at key steps in the differentiation of
cell types in the mammalian CNS. Neuroepithelial stem cells express the intermediate …

Amygdalo‐cortical sprouting continues into early adulthood: Implications for the development of normal and abnormal function during adolescence

MG Cunningham, S Bhattacharyya… - Journal of comparative …, 2002 - Wiley Online Library
Adolescence is a critical stage for the development of emotional maturity and diverse forms
of psychopathology. The posterior basolateral nucleus of the amygdala is known to mediate …

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain

PJ Renfranz, MG Cunningham, RDG McKay - Cell, 1991 - cell.com
Proliferating precursors to the distinct cell types constituting the mammalian brain can be
identified by the presence of the nestin intermediate filament. We report the establishment of …

[PDF][PDF] hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice

M Cunningham, JH Cho, A Leung, G Savvidis, S Ahn… - Cell stem cell, 2014 - cell.com
Seizure disorders debilitate more than 65,000,000 people worldwide, with temporal lobe
epilepsy (TLE) being the most common form. Previous studies have shown that …

Pig models of neurodegenerative disorders: Utilization in cell replacement‐based preclinical safety and efficacy studies

D Dolezalova, M Hruska‐Plochan… - Journal of …, 2014 - Wiley Online Library
An important component for successful translation of cell replacement‐based therapies into
clinical practice is the utilization of large animal models to conduct efficacy and/or safety cell …

Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model

G Nikkhah, MG Cunningham, A Jo, U Knappe, A Bjo - Brain research, 1994 - Elsevier
A microtransplantation approach has been used in order to achieve more complete
reinnervation of the dopamine denervated rat striatum by fetal nigral cell suspensions …

Increasing interaction of amygdalar afferents with GABAergic interneurons between birth and adulthood

MG Cunningham, S Bhattacharyya, FM Benes - Cerebral Cortex, 2008 - academic.oup.com
Previous work in animal models has shown that projections from the basolateral amygdala
(BLA) progressively infiltrate the medial prefrontal cortex (mPFC) from birth to adulthood …

Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

JA Honeycutt, C Demaestri, S Peterzell, MM Silveri… - Elife, 2020 - elifesciences.org
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated
with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have …