[HTML][HTML] The inducible caspase-9 suicide gene system as a “safety switch” to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells

T Gargett, MP Brown - Frontiers in pharmacology, 2014 - frontiersin.org
Immune modulation has become a central element in many cancer treatments, and T cells
genetically engineered to express chimeric antigen receptors (CAR) may provide a new …

[HTML][HTML] A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

JD Mellor, MP Brown, HR Irving, JR Zalcberg… - Journal of hematology & …, 2013 - Springer
Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of
therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab …

[HTML][HTML] Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required?

AH Staudacher, MP Brown - British journal of cancer, 2017 - nature.com
Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific
monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the …

Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial

GS Falchook, GV Long, R Kurzrock, KB Kim… - The Lancet, 2012 - thelancet.com
Background Dabrafenib is an inhibitor of BRAF kinase that is selective for mutant BRAF. We
aimed to assess its safety and tolerability and to establish a recommended phase 2 dose in …

Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study

GV Long, V Atkinson, S Lo, S Sandhu… - The Lancet …, 2018 - thelancet.com
Background Nivolumab monotherapy and combination nivolumab plus ipilimumab increase
proportions of patients achieving a response and survival versus ipilimumab in patients with …

[BOOK][B] Closet space: Geographies of metaphor from the body to the globe

MP Brown - 2005 - taylorfrancis.com
Is the closet just a metaphor? Closet Space provides a highly original account of the spatial
metaphor of" the closet", and is the first geography text to focus on this important issue …

[BOOK][B] Replacing citizenship: AIDS activism and radical democracy

MP Brown - 1997 - books.google.com
This book uses an ethnographic study of one gay community's responses to AIDS to
illustrate a radical democratic understanding of citizenship in contemporary society …

Vemurafenib in patients with BRAFV600 mutated metastatic melanoma: an open-label, multicentre, safety study

J Larkin, M Del Vecchio, PA Ascierto, I Krajsova… - The Lancet …, 2014 - thelancet.com
Background The orally available BRAF kinase inhibitor vemurafenib, compared with
dacarbazine, shows improved response rates, progression-free survival (PFS), and overall …

[HTML][HTML] GD2-specific CAR T cells undergo potent activation and deletion following antigen encounter but can be protected from activation-induced cell death by PD-1 …

T Gargett, W Yu, G Dotti, ES Yvon, SN Christo… - Molecular Therapy, 2016 - cell.com
Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of
hematologic malignancies but more variable results in the treatment of solid tumors and the …

[HTML][HTML] Total percutaneous access for endovascular aortic aneurysm repair (“Preclose” technique)

WA Lee, MP Brown, PR Nelson, TS Huber - Journal of vascular surgery, 2007 - Elsevier
OBJECTIVE: Percutaneous access during endovascular aneurysm repair has been difficult
owing to the large size of the delivery catheters. This study reports a single-center …