Gene-transfer vectors based on lentiviruses are distinguished by their ability to transduce
non-dividing cells 1, 2. The HIV-1 proteins Matrix, Vpr and Integrase have been implicated in …

In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …

Personalized cancer medicine is based on the concept that targeted therapies are effective
on subsets of patients whose tumors carry specific molecular alterations. Several …

The natural history of B‐chronic lymphocytic leukemia (CLL) is not entirely explained by
intrinsic defects of the neoplastic cell, but is also favored by microenvironmental signals. As …

Prolactin (PRL) enhances inflammatory and antitumor responses in vitro and thus exhibits
Th1-type cytokine-like effects. Evidence from experimental models indicates that inhibition of …

Chronic lymphocytic leukemia (CLL) has a variable clinical course. CD38 expression and
IgVH gene mutational status are independent predictors of prognosis, but their relationships …

The responsiveness and diversity of peripheral B-cell repertoire decreases with age,
possibly because of B-cell clonal expansions, as suggested by the incidence of serum …

Abstract Interferon‐γ (IFN‐γ) is produced by activated T lymphocytes and plays a regulatory
role in immune responses. The nature and location of cells that express the IFN‐γ receptor …

Donor-derived cytokine-induced killer (CIK) can be infused as adoptive immunotherapy after
hematopoietic cell transplant (HCT). Promising results were recently reported in HLA …

Growth and survival of chronic B-cell tumors are favored by the malignant cell's capacity to
respond to selected microenvironmental stimuli provided by nontumoral bystander cells. To …