Purpose Many seriously ill patients with cancer do not discuss prognosis or advance
directives (ADs), which may lead to inappropriate and/or unwanted aggressive care at the …

There was no change in responses to the Herth Hope Index after the intervention (see
Figure 1). In most cases the responses were completely unchanged. For this 12-point scale …

Most cancer patients do not have an explicit discussion about prognosis and treatment
despite documented adverse outcomes. Few decision aids have been developed to assist …

Abnormalities in taste and smell are commonly reported in patients receiving chemotherapy
and may hinder appetite, dietary intake, nutritional well-being, and quality of life. Oral zinc …

Background: Immune checkpoint inhibitors have changed the landscape of cancer care by
increasing progression-free and overall survival in some patients with cancer. We evaluated …

Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a
result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other …

Background: Immune checkpoint inhibitors (ICIs) have revolutionized treatment for many
patients with advanced cancer. Little is known about ICI use near the end of life. Objective …

Introduction: Pulmonary arterial hypertension (PAH) is a progressive and ultimately fatal
disease of the pulmonary circulation. There has never been an investigation of the end-of …

While there is no generally accepted medical definition of" futile care," many factors may
play a role in the delivery of chemotherapy to patients who are unlikely to benefit. In this …

To the Editor: A 49-year-old man with history of schizoaffective disorder and psoriasis
received pembrolizumab for metastatic thymic carcinoma. Before starting immune …