User profiles for "author:Julian Gunn"

Julian Gunn

Professor of Interventional Cardiology, University of Sheffield
Verified email at sheffield.ac.uk
Cited by 7953

[HTML][HTML] Computational fluid dynamics modelling in cardiovascular medicine

PD Morris, A Narracott, H von Tengg-Kobligk… - Heart, 2016 - heart.bmj.com
This paper reviews the methods, benefits and challenges associated with the adoption and
translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine …

[PDF][PDF] Coronary stents: historical development, current status and future directions.

J Iqbal, J Gunn, PW Serruys - British medical bulletin, 2013 - Citeseer
Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world.
Central to the pathogenesis of CAD is the development of atherosclerotic lesions in coronary …

A collaborative systematic review and meta-analysis on 1278 patients undergoing percutaneous drug-eluting stenting for unprotected left main coronary artery …

GGL Biondi-Zoccai, M Lotrionte, C Moretti, E Meliga… - American heart …, 2008 - Elsevier
BACKGROUND: Cardiac surgery is the standard treatment for unprotected left main disease
(ULM). Drug-eluting stent (DES) implantation has been recently reported in patients with …

Virtual fractional flow reserve from coronary angiography: modeling the significance of coronary lesions: results from the VIRTU-1 (VIRTUal Fractional Flow Reserve …

PD Morris, D Ryan, AC Morton, R Lycett… - JACC: Cardiovascular …, 2013 - jacc.org
Objectives: The aim of this study was to develop a computer model that accurately predicts
myocardial fractional flow reserve (FFR) from angiographic images alone, in patients with …

The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study

AC Morton, AMK Rothman, JP Greenwood… - European heart …, 2015 - academic.oup.com
Abstract Aims Acute coronary syndromes (ACSs) are driven by inflammation within coronary
plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel …

Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease

SE Francis, NJ Camp, RM Dewberry, J Gunn, P Syrris… - Circulation, 1999 - Am Heart Assoc
Background—Cytokine gene variations are contributory factors in inflammatory pathology.
Allele frequencies of interleukin (IL)-1 cluster genes [IL-1A (-889), IL-1B (-511), IL-1B (+ …

Optimal medical therapy improves clinical outcomes in patients undergoing revascularization with percutaneous coronary intervention or coronary artery bypass …

J Iqbal, YJ Zhang, DR Holmes, MC Morice, MJ Mack… - Circulation, 2015 - Am Heart Assoc
Background—There is a paucity of data on the use of optimal medical therapy (OMT) in
patients with complex coronary artery disease undergoing revascularization with …

“Virtual”(computed) fractional flow reserve: current challenges and limitations

PD Morris, FN van de Vosse, PV Lawford… - JACC: Cardiovascular …, 2015 - jacc.org
Fractional flow reserve (FFR) is the “gold standard” for assessing the physiological
significance of coronary artery disease during invasive coronary angiography. FFR-guided …

The influence of physical stent parameters upon restenosis

AC Morton, D Crossman, J Gunn - Pathologie Biologie, 2004 - Elsevier
In this paper we examine whether the structure, geometry and dimensions of coronary stents
influence the occurrence of restenosis. Whilst many consider these parameters to be less …

The effects of stenting on shear stress: relevance to endothelial injury and repair

K Van der Heiden, FJH Gijsen, A Narracott… - Cardiovascular …, 2013 - academic.oup.com
Stent deployment following balloon angioplasty is used routinely to treat coronary artery
disease. These interventions cause damage and loss of endothelial cells (EC), and thus …