User profiles for "author:Hui Gan"

Hui Gan

Guangzhou medical college,Zhongnan hospital of Wuhan University,Wuhan Pulmonary …
Verified email at stu.gzhmu.edu.cn
Cited by 1602

Risk factors for severe and critically ill COVID‐19 patients: a review

Y Gao, M Ding, X Dong, J Zhang, A Kursat Azkur… - Allergy, 2021 - Wiley Online Library
The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global …

The EGFRvIII variant in glioblastoma multiforme

HK Gan, AH Kaye, RB Luwor - Journal of Clinical Neuroscience, 2009 - Elsevier
Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst
prognosis. Epidermal growth factor receptor (EGFR) gene amplification, mutation and re …

The epidermal growth factor receptor variant III (EGFR v III): where wild things are altered

HK Gan, AN Cvrljevic, TG Johns - The FEBS journal, 2013 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human
epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene …

Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck …

B Burtness, KJ Harrington, R Greil, D Soulières… - The Lancet, 2019 - thelancet.com
Background Pembrolizumab is active in head and neck squamous cell carcinoma (HNSCC),
with programmed cell death ligand 1 (PD-L1) expression associated with improved …

[PDF][PDF] Glioma progression is shaped by genetic evolution and microenvironment interactions

FS Varn, KC Johnson, J Martinek, JT Huse… - Cell, 2022 - cell.com
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify
treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …

[HTML][HTML] Antibody–drug conjugates for cancer therapy

U Hafeez, S Parakh, HK Gan, AM Scott - Molecules, 2020 - mdpi.com
Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a
monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the …

Longitudinal molecular trajectories of diffuse glioma in adults

FP Barthel, KC Johnson, FS Varn, AD Moskalik… - Nature, 2019 - nature.com
The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear,. Here we analysed temporally separated DNA-sequencing …

A systematic review of adverse events in randomized trials assessing immune checkpoint inhibitors

P Arnaud‐Coffin, D Maillet, HK Gan… - … journal of cancer, 2019 - Wiley Online Library
The advent of immune checkpoint‐inhibitors (CPI) has transformed treatment for several
cancer types. This review was performed to assess the rate of adverse events (AEs) …

Melatonin ameliorates nonalcoholic fatty liver induced by high‐fat diet in rats

M Pan, YL Song, JM Xu, HZ Gan - Journal of pineal research, 2006 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized condition that may
progress to end‐stage liver disease, which ranges from simple steatosis to steatohepatitis …

Understanding the activity of antibody–drug conjugates in primary and secondary brain tumours

MJ Mair, R Bartsch, E Le Rhun, AS Berghoff… - Nature Reviews …, 2023 - nature.com
Abstract Antibody–drug conjugates (ADCs), a class of targeted cancer therapeutics
combining monoclonal antibodies with a cytotoxic payload via a chemical linker, have …