Vascular and lymphatic malformations represent a challenge for clinicians. The identification
of inherited and somatic mutations in important signaling pathways, including the PI3K …

Vascular malformations are inborn errors of vascular morphogenesis and consist of
localized networks of abnormal blood and/or lymphatic vessels with weak endothelial cell …

Vascular malformations are subdivided into capillary, lymphatic, venous, arteriovenous, and
mixed malformations, according to the type of affected vessels. Until a few years ago …

Background Metastatic castration-resistant prostate cancers are enriched for DNA repair
gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP …

Venous malformations (VMs) are composed of ectatic veins with scarce smooth muscle cell
coverage. Activating mutations in the endothelial cell tyrosine kinase receptor TIE2 are a …

Background Extensive and complex vascular malformations often cause chronic pain and
severe functional restraint. Conventional treatments, such as surgery and/or sclerotherapy …

High lactate concentration in tumors is associated with bad prognosis. Lactate is released by
glycolytic cells in tumors and recaptured by oxidative cancer cells to feed the tricarboxylic …

Background This phase II study assessed the safety and efficacy of everolimus, an oral
mammalian target of rapamycin inhibitor in advanced transitional carcinoma cell (TCC) after …

Importance Patients with brain metastases from renal cell carcinoma (RCC) have been
underrepresented in clinical trials, and effective systemic therapy is lacking. Cabozantinib …

With an incidence of approximately 1 in 2,000 to 5,000, venous malformations (VMs)
represent a vascular malformation frequently observed in specialized multidisciplinary …