[HTML][HTML] The use of validated and nonvalidated surrogate endpoints in two European Medicines Agency expedited approval pathways: a cross-sectional study of …

C Schuster Bruce, P Brhlikova, J Heath… - PLoS …, 2019 - journals.plos.org
Background In situations of unmet medical need or in the interests of public health,
expedited approval pathways, including conditional marketing authorisation (CMA) and …

[HTML][HTML] The use of validated and nonvalidated surrogate endpoints in two European Medicines Agency expedited approval pathways: a cross-sectional study of …

CS Bruce, P Brhlikova, J Heath, P McGettigan - PLoS medicine, 2019 - ncbi.nlm.nih.gov
Background In situations of unmet medical need or in the interests of public health,
expedited approval pathways, including conditional marketing authorisation (CMA) and …

Managing acute respiratory tract infections in children

CS Bruce, C Hoare, A Mukherjee… - British Journal of …, 2017 - magonlinelibrary.com
Respiratory tract infections (RTIs), including community-acquired pneumonia (CAP),
bronchiolitis, viral-induced wheeze and croup, account for more primary care consultations …

Novel stratified medicines approach to manage uncontrolled hypertension due to multiple drug intolerances

CS Bruce, G Rull, A Sotiris, MD Lobo - BMJ Case Reports CP, 2018 - casereports.bmj.com
A 61-year-old man with a 30-year history of uncontrolled hypertension was unable to
tolerate conventional antihypertensive medications from all classes. At the time of referral to …

Childhood constipation: recognition, management and the role of the nurse

JS Bruce, CS Bruce, H Short… - British Journal of …, 2016 - magonlinelibrary.com
Constipation is a common childhood condition that health professionals will encounter in
many different settings. The majority of these cases of childhood constipation are idiopathic …