Physiological processes such as the sleep-wake cycle, metabolism and hormone secretion
are controlled by a circadian rhythm adapted to 24 h day-night periodicity. This circadian …

Gliomas harboring mutations in isocitrate dehydrogenase 1/2 (IDH1/2) have the CpG island
methylator phenotype (CIMP) and significantly longer patient survival time than wild-type …

Deregulated glucose metabolism fulfills the energetic and biosynthetic requirements for
tumor growth driven by oncogenes. Because inhibition of oncogenic BRAF causes profound …

Mammalian embryogenesis requires rapid growth and proper metabolic regulation.
Midgestation features increasing oxygen and nutrient availability concomitant with fetal …

Iris cysts though uncommon, present diagnostic and therapeutic challenges. With the advent
of better investigational modalities it is not so difficult to characterize iris cysts and …

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell
carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts …

In mice and humans with cancer, intravenous 13C-glucose infusion results in 13C labeling
of tumor tricarboxylic acid (TCA) cycle intermediates, indicating that pyruvate oxidation in the …

This study examined the effects of training in a pure tone discrimination task on relations
between behavioral performance and the magnitude of auditory event-related potentials …

Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen
receptor-positive breast cancer and are currently in clinical development in melanoma, a …

BRAF and MEK inhibitors are not established treatments for non-V600 mutation-positive
metastatic melanoma. We carried out a retrospective analysis of efficacy and safety in four …