What is diabetes?

AM Egan, SF Dinneen - Medicine, 2019 - Elsevier
Diabetes mellitus represents a set of autoimmune, metabolic and genetic disorders that
share one major characteristic–hyperglycaemia. The recommended way of measuring …

A review of the pathophysiology and management of diabetes in pregnancy

AM Egan, ML Dow, A Vella - Mayo Clinic Proceedings, 2020 - Elsevier
Diabetes is a common metabolic complication of pregnancy and affected women fall into two
subgroups: women with pre-existing diabetes and those with gestational diabetes mellitus …

[HTML][HTML] A core outcome set for studies of gestational diabetes mellitus prevention and treatment

AM Egan, D Bogdanet, TP Griffin, O Kgosidialwa… - Diabetologia, 2020 - Springer
Aims/hypothesis The aim of this systematic review was to develop core outcome sets (COSs)
for trials evaluating interventions for the prevention or treatment of gestational diabetes …

[HTML][HTML] Epidemiology of gestational diabetes mellitus according to IADPSG/WHO 2013 criteria among obese pregnant women in Europe

AM Egan, A Vellinga, J Harreiter, D Simmons… - Diabetologia, 2017 - Springer
Aims/hypothesis Accurate prevalence estimates for gestational diabetes mellitus (GDM)
among pregnant women in Europe are lacking owing to the use of a multitude of diagnostic …

ATLANTIC-DIP: excessive gestational weight gain and pregnancy outcomes in women with gestational or pregestational diabetes mellitus

AM Egan, MC Dennedy, W Al-Ramli… - The Journal of …, 2014 - academic.oup.com
Context: Women who have diabetes mellitus during pregnancy are at higher risk of adverse
outcomes. Excessive gestational weight gain (GWG) is also emerging as a risk factor for …

[HTML][HTML] Use of core outcome sets was low in clinical trials published in major medical journals

K Matvienko-Sikar, K Avery, JM Blazeby… - Journal of clinical …, 2022 - Elsevier
Objectives To examine current practices in late-phase trials published in major medical
journals and examine trialists' views about core outcome set (COS) use. Study Design and …

[HTML][HTML] Diabetic retinopathy in pregnancy: a population-based study of women with pregestational diabetes

AM Egan, L McVicker, A Heerey, L Carmody… - Journal of diabetes …, 2015 - hindawi.com
The aim of this observational study was to evaluate screening and progression of diabetic
retinopathy during pregnancy in women with pregestational diabetes attending five …

[HTML][HTML] Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans

AA Welch, RA Farahani, AM Egan… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Proglucagon can be processed to glucagon-like peptide1 (GLP-1) within
the islet, but its contribution to islet function in humans remains unknown. We sought to …

[PDF][PDF] Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes

N Javeed, TK Her, MR Brown, P Vanderboom… - Cell reports, 2021 - cell.com
Coordinated communication among pancreatic islet cells is necessary for maintenance of
glucose homeostasis. In diabetes, chronic exposure to pro-inflammatory cytokines has been …

Ten years of optimizing outcomes for women with type 1 and type 2 diabetes in pregnancy—the Atlantic DIP experience

LA Owens, AM Egan, L Carmody… - The Journal of Clinical …, 2016 - academic.oup.com
Context: Pregnancy for women with type 1 or type 2 diabetes is a time of increased risk for
both mother and baby. The Atlantic Diabetes in Pregnancy program provides coordinated …