Genetics of osteoporosis

QY Huang, AWC Kung - Molecular Genetics and Metabolism, 2006 - Elsevier
Osteoporosis is a common disease with a strong genetic component. In recent years, some
progress has been made in understanding the genetic basis of osteoporosis. Genetic factors …

[HTML][HTML] Low handgrip strength is a predictor of osteoporotic fractures: cross-sectional and prospective evidence from the Hong Kong Osteoporosis Study

CL Cheung, KCB Tan, CH Bow, CSS Soong… - Age, 2012 - Springer
Handgrip strength (HGS) is a potentially useful objective parameter to predict fracture since
it is an indicator of general muscle strength and is associated with fragility and propensity to …

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium

A Moayyeri, YH Hsu, D Karasik… - Human molecular …, 2014 - academic.oup.com
Quantitative ultrasound of the heel captures heel bone properties that independently predict
fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be …

Patients with osteoporosis prefer once weekly to once daily dosing with alendronate

D Kendler, AWC Kung, GEH Fuleihan, JGG González… - Maturitas, 2004 - Elsevier
Objectives: Once weekly dosing of alendronate has been shown to provide equivalent
efficacy to once daily dosing for treatment of osteoporosis in postmenopausal women …

Association of genetic variants related to serum calcium levels with reduced bone mineral density

GHY Li, C Robinson-Cohen, S Sahni… - The Journal of …, 2020 - academic.oup.com
Context The role of serum calcium in bone metabolism is unknown, even though
calcium/vitamin D supplementations have been widely used and are expected to improve …

[HTML][HTML] Osteoporosis is a novel risk factor of infections and sepsis: A cohort study

X Zhang, KW Man, GHY Li, KCB Tan, AWC Kung… - …, 2022 - thelancet.com
Background Accumulating evidence suggests the interaction of bone metabolism and the
immune system, but how bone health is associated with the risk of infections remains …

Ten-year fracture probability in Hong Kong Southern Chinese according to age and BMD femoral neck T-scores

SWY Tsang, AWC Kung, JA Kanis, H Johansson… - Osteoporosis …, 2009 - Springer
This study estimated the 10-year probability of osteoporotic fracture in Hong Kong Southern
Chinese based on a simplified model of the recently developed WHO fracture risk prediction …

Hypokalemic periodic paralysis due to the Sjögren syndrome in Chinese patients

KK Pun, CK Wong, EYL Tsui, SCF Tam… - Annals of Internal …, 1989 - acpjournals.org
Excerpt The Sjögren syndrome is complicated by distal renal tubular acidosis in about 40%
of the patients (1). Three patients presented with hypokalemic paralysis as a result of renal …

Association of Bone Mineral Density and Bone Turnover Markers with the Risk of Diabetes: Hong Kong Osteoporosis Study and Mendelian Randomization

X Zhang, S Krishnamoorthy, CTL Tang… - Journal of Bone and …, 2023 - academic.oup.com
Preclinical studies demonstrated that bone plays a central role in energy metabolism.
However, how bone metabolism is related to the risk of diabetes in humans is unknown. We …

The Action of Methimazole and L-Thyroxine in Radioiodine Therapy: A Prospective Study on the Incidence of Hypothyroidism

AWC Kung, CC Yau, ACK Cheng - Thyroid, 1995 - liebertpub.com
Thiourea drugs have been postulated to possess radioprotective property. We studied the
effect of adjunctive antithyroid drugs (ATD) and l-thyroxine (l-T4) on the result of radioiodine …