Chronic toxicology of cannabis

AS Reece - Clinical toxicology, 2009 - Taylor & Francis
Introduction. Cannabis is the most widely used illicit drug worldwide. As societies reconsider
the legal status of cannabis, policy makers and clinicians require sound knowledge of the …

[HTML][HTML] Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development

AS Reece, GK Hulse - Scientific reports, 2021 - nature.com
Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and
chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely …

Chromothripsis and epigenomics complete causality criteria for cannabis-and addiction-connected carcinogenicity, congenital toxicity and heritable genotoxicity

AS Reece, GK Hulse - Mutation Research/Fundamental and Molecular …, 2016 - Elsevier
The recent demonstration that massive scale chromosomal shattering or pulverization can
occur abruptly due to errors induced by interference with the microtubule machinery of the …

[HTML][HTML] Geotemporospatial and causal inference epidemiological analysis of US survey and overview of cannabis, cannabidiol and cannabinoid genotoxicity in …

AS Reece, GK Hulse - BMC pediatrics, 2022 - Springer
Background Cannabinoids including cannabidiol have recognized genotoxic activities but
their significance has not been studied broadly epidemiologically across the teratological …

Cannabis teratology explains current patterns of Coloradan congenital defects: the contribution of increased cannabinoid exposure to rising teratological trends

AS Reece, GK Hulse - Clinical Pediatrics, 2019 - journals.sagepub.com
Rising Δ9-tetrahydrocannabinol concentrations in modern cannabis invites investigation of
the teratological implications of prenatal cannabis exposure. Data from Colorado Responds …

[HTML][HTML] Canadian cannabis consumption and patterns of congenital anomalies: an ecological geospatial analysis

AS Reece, GK Hulse - Journal of addiction medicine, 2020 - journals.lww.com
Objectives: Cannabis is a known teratogen. Data availability addressing both major
congenital anomalies and cannabis use allowed us to explore their geospatial relationships …

[HTML][HTML] Clinical epigenomic explanation of the epidemiology of cannabinoid genotoxicity manifesting as transgenerational teratogenesis, cancerogenesis and aging …

AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2023 - mdpi.com
As global interest in the therapeutic potential of cannabis and its' derivatives for the
management of selected diseases increases, it is increasingly imperative that the toxic …

Cannabinoid and substance relationships of European congenital anomaly patterns: a space-time panel regression and causal inferential study

AS Reece, GK Hulse - Environmental Epigenetics, 2022 - academic.oup.com
Abstract With reports from Australia, Canada, USA, Hawaii and Colorado documenting a link
between cannabis and congenital anomalies (CAs), this relationship was investigated in …

Cannabis exposure as an interactive cardiovascular risk factor and accelerant of organismal ageing: a longitudinal study

AS Reece, A Norman, GK Hulse - BMJ open, 2016 - bmjopen.bmj.com
Objectives Many reports exist of the cardiovascular toxicity of smoked cannabis but none of
arterial stiffness measures or vascular age (VA). In view of its diverse toxicology, the …

[HTML][HTML] Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers

AS Reece - Immunity & Ageing, 2007 - Springer
Background Drug addiction is associated with significant disease and death, but its impact
on the ageing process has not been considered. The recent demonstration that many of the …