The aging population is increasing in developed countries. Because the incidence of
cardiac disease increases dramatically with age, it is important to understand the molecular …

Mitochondria are essential organelles that produce the cellular energy source, ATP.
Dysfunctional mitochondria are involved in the pathophysiology of heart disease, which is …

Rationale: Both fusion and fission contribute to mitochondrial quality control. How
unopposed fusion affects survival of cardiomyocytes and left ventricular function in the heart …

Background—Mitochondrial autophagy is an important mediator of mitochondrial quality
control in cardiomyocytes. The occurrence of mitochondrial autophagy and its significance …

Rationale: Diabetic patients develop cardiomyopathy characterized by hypertrophy, diastolic
dysfunction, and intracellular lipid accumulation, termed lipotoxicity. Diabetic hearts utilize …

Background: Trehalose (TRE) is a natural, nonreducing disaccharide synthesized by lower
organisms. TRE exhibits an extraordinary ability to protect cells against different kinds of …

Background Cardiogenic shock (CS) is caused by primary cardiac dysfunction and induced
by various and heterogeneous diseases (eg, acute impairment of cardiac performance, or …

Patients with heart failure (HF) are sometimes classified as malnourished, but the prognostic
value of nutritional status in acute HF (AHF) remains largely unstudied. 1214 patients who …

Rationale: In Drosophila, the Hippo signaling pathway negatively regulates organ size by
suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional …

Rationale: Obesity-associated cardiomyopathy characterized by hypertrophy and
mitochondrial dysfunction. Mitochondrial quality control mechanisms, including mitophagy …