Calcium pyrophosphate dihydrate crystal deposition disease and MRSA septic arthritis of the atlantoaxial joint in a patient with Tourette syndrome

BMJ Case Rep. 2019 Mar 22;12(3):e228102. doi: 10.1136/bcr-2018-228102.

Abstract

A 45-year-old male patient with Tourette syndrome presented to the emergency department with worsening neck pain and stiffness of 1-week duration. Associated symptoms included headache, hoarse voice, trismus and odynophagia. The patient was haemodynamically stable without fevers or leucocytosis. He exhibited cervical spinal and paraspinal tenderness with very limited range of motion. Erythrocyte sedimentation rate and C reactive protein were elevated, and blood cultures grew methicillin-resistant Staphylococcus aureus (MRSA). Lumbar puncture was unremarkable. CT and MRI of the neck showed calcification of the longus colli, fluid and capsular distention of C1-C2 joints, enhancement of the joint capsule and retropharyngeal oedema suggestive of septic arthritis. Fluid was aspirated from C1 to C2 joint by interventional radiology and showed calcium pyrophosphate crystals and heavy MRSA colonisation, consistent with both pseudogout and septic arthritis of the cervical vertebrae. The patient was started on a 6-week course of daptomycin and showed gradual improvements in neck pain and mobility.

Keywords: bone and joint infections; movement disorders (other than Parkinsons); rheumatology.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Infectious / drug therapy
  • Arthritis, Infectious / metabolism
  • Arthritis, Infectious / microbiology*
  • Atlanto-Axial Joint / diagnostic imaging*
  • Atlanto-Axial Joint / metabolism
  • Atlanto-Axial Joint / microbiology
  • Calcium Pyrophosphate / metabolism*
  • Daptomycin / administration & dosage
  • Daptomycin / pharmacology
  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Middle Aged
  • Staphylococcal Infections / diagnosis*
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / metabolism
  • Tomography, X-Ray Computed
  • Tourette Syndrome
  • Treatment Outcome

Substances

  • Daptomycin
  • Calcium Pyrophosphate