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Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.
Daruwalla C, Shaygannejad V, Ozakbas S, Havrdova EK, Horakova D, Alroughani R, Boz C, Patti F, Onofrj M, Lugaresi A, Eichau S, Girard M, Prat A, Duquette P, Yamout B, Khoury SJ, Sajedi SA, Turkoglu R, Altintas A, Skibina O, Buzzard K, Grammond P, Karabudak R, van der Walt A, Butzkueven H, Maimone D, Lechner-Scott J, Soysal A, John N, Prevost J, Spitaleri D, Ramo-Tello C, Gerlach O, Iuliano G, Foschi M, Ampapa R, van Pesch V, Barnett M, Shalaby N, D'hooghe M, Kuhle J, Sa MJ, Fabis-Pedrini M, Kermode A, Mrabet S, Gouider R, Hodgkinson S, Laureys G, Van Hijfte L, Macdonell R, Oreja-Guevara C, Cristiano E, McCombe P, Sanchez-Menoyo JL, Singhal B, Blanco Y, Hughes S, Garber J, Solaro C, McGuigan C, Taylor B, de Gans K, Habek M, Al-Asmi A, Mihaela S, Castillo Triviño T, Al-Harbi T, Rojas JI, Gray O, Khurana D, Van Wijmeersch B, Grigoriadis N, Inshasi J, Oh J, Aguera-Morales E, Fragoso Y, Moore F, Shaw C, Baghbanian SM, Shuey N, Willekens B, Hardy TA, Decoo D, Sempere AP, Field D, Wynford-Thomas R, Cunniffe NG, Roos I, Malpas CB, Coles AJ, Kalincik T, Brown JWL. Daruwalla C, et al. Among authors: cunniffe ng. Mult Scler. 2023 Jun;29(7):875-883. doi: 10.1177/13524585231151951. Epub 2023 Feb 27. Mult Scler. 2023. PMID: 36851894 Free PMC article.
Visual outcome measures in clinical trials of remyelinating drugs.
Riboni-Verri G, Chen BS, McMurran CE, Halliwell GJ, Brown JWL, Coles AJ, Cunniffe NG. Riboni-Verri G, et al. Among authors: cunniffe ng. BMJ Neurol Open. 2024 Feb 19;6(1):e000560. doi: 10.1136/bmjno-2023-000560. eCollection 2024. BMJ Neurol Open. 2024. PMID: 38389586 Free PMC article. Review.
Remyelination in humans due to a retinoid-X receptor agonist is age-dependent.
McMurran CE, Mukherjee T, Brown JWL, Michell AW, Chard DT, Franklin RJM, Coles AJ, Cunniffe NG. McMurran CE, et al. Among authors: cunniffe ng. Ann Clin Transl Neurol. 2022 Jul;9(7):1090-1094. doi: 10.1002/acn3.51595. Epub 2022 May 19. Ann Clin Transl Neurol. 2022. PMID: 35587315 Free PMC article.
Remyelination varies between and within lesions in multiple sclerosis following bexarotene.
Brown JWL, Prados F, Altmann DR, Kanber B, Stutters J, Cunniffe NG, Jones JL, Georgieva ZG, Needham EJ, Daruwalla C, Wheeler-Kingshott CG, Connick P, Chandran S, Franklin R, MacManus D, Samson R, Coles A, Chard D. Brown JWL, et al. Among authors: cunniffe ng. Ann Clin Transl Neurol. 2022 Oct;9(10):1626-1642. doi: 10.1002/acn3.51662. Epub 2022 Sep 17. Ann Clin Transl Neurol. 2022. PMID: 36116011 Free PMC article.
How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis.
Cunniffe NG, Gunter SJ, Brown M, Burge SW, Coyle C, De Soyza A, Dymond T, Esmail H, Francis DP, Galloway J, Galloway JB, Gkrania-Klotsas E, Greenaway J, Katritsis G, Kanagaratnam P, Knolle MD, Leonard K, McIntyre ZC, Prudon B, Rampling T, Torok ME, Warne B, Yates M, Matheson NJ, Su L, Villar S, Stewart GD, Toshner M. Cunniffe NG, et al. BMJ Open. 2020 Oct 5;10(10):e044566. doi: 10.1136/bmjopen-2020-044566. BMJ Open. 2020. PMID: 33020111 Free PMC article.
Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.
Brown JWL, Cunniffe NG, Prados F, Kanber B, Jones JL, Needham E, Georgieva Z, Rog D, Pearson OR, Overell J, MacManus D, Samson RS, Stutters J, Ffrench-Constant C, Gandini Wheeler-Kingshott CAM, Moran C, Flynn PD, Michell AW, Franklin RJM, Chandran S, Altmann DR, Chard DT, Connick P, Coles AJ. Brown JWL, et al. Among authors: cunniffe ng. Lancet Neurol. 2021 Sep;20(9):709-720. doi: 10.1016/S1474-4422(21)00179-4. Lancet Neurol. 2021. PMID: 34418398 Clinical Trial.
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