We present the case of a patient who ingested approximately 3.57 g of caffeine in a suicide attempt and developed rhabdomyolysis and acute renal failure. After a delay in diagnosis, the patient was hospitalized and rapidly improved with peritoneal dialysis and volume expansion, but was left with residual impairment of renal function on discharge. This case represents a rarely reported complication of caffeine intoxication, rhabdomyolysis, which occurred in the absence of other toxins or conditions that predispose to muscle necrosis.