Histology and molecular aspects of central neurocytoma

Phillip A Bonney; Lillian B Boettcher; Richard S Krysiak 3rd; Kar-Ming Fung; Michael E Sughrue

doi:10.1016/j.nec.2014.09.001

Histology and molecular aspects of central neurocytoma

Neurosurg Clin N Am. 2015 Jan;26(1):21-9. doi: 10.1016/j.nec.2014.09.001.

Authors

Phillip A Bonney¹, Lillian B Boettcher¹, Richard S Krysiak 3rd¹, Kar-Ming Fung², Michael E Sughrue³

Affiliations

¹ Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 North Lincoln Boulevard, Suite 4000, Oklahoma City, OK 73104, USA.
² Department of Pathology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, BMSB 451, Oklahoma City, OK 73104, USA.
³ Department of Neurosurgery, University of Oklahoma Health Sciences Center, 1000 North Lincoln Boulevard, Suite 4000, Oklahoma City, OK 73104, USA; Oklahoma Comprehensive Brain Tumor Clinic, Oklahoma City, OK 73104, USA. Electronic address: michael-sughrue@ouhsc.edu.

PMID: 25432180
DOI: 10.1016/j.nec.2014.09.001

Abstract

Central neurocytoma (CN) is a well-differentiated tumor of neural cells occurring within the ventricles. It is composed of monomorphic cells with round, regular nuclei within clear cytoplasm and must be distinguished from other clear cell tumors. Immunohistochemical markers of CN that aid in diagnosis include synaptophysin and neuronal nuclear antigen. The molecular biology of these tumors is becoming increasingly elucidated, particularly with the use of microarray analyses. Several oncogenic pathways have been suggested by these studies. Although progress continues to be made, knowledge of CN has yet to dictate targeted therapies in treating patients with these tumors.

Keywords: Brain tumor; Central neurocytoma; Histology; Molecular pathways; Review.

Publication types

Review

MeSH terms

Cerebral Ventricle Neoplasms / genetics*
Cerebral Ventricle Neoplasms / pathology
Humans
Neurocytoma / genetics*
Neurocytoma / pathology