Avascular necrosis in a HIV patient receiving ritonavir and inhaled fluticasone

S Pollett; B Graves; B Richards; C MacLeod

doi:10.1177/0956462413513747

Avascular necrosis in a HIV patient receiving ritonavir and inhaled fluticasone

Int J STD AIDS. 2014 May;25(6):458-60. doi: 10.1177/0956462413513747. Epub 2013 Nov 28.

Authors

S Pollett¹, B Graves, B Richards, C MacLeod

Affiliation

¹ Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

PMID: 24287027
DOI: 10.1177/0956462413513747

Abstract

We report a case of severe bilateral knee avascular necrosis in a HIV-positive man receiving ritonavir and inhaled fluticasone. This case highlights the need for a thorough medication history in patients on ritonavir-based antiretroviral therapy, especially where multiple prescribers are involved in the patient's care.

Keywords: AIDS; HIV; antiretroviral therapy; avascular necrosis; drug interactions; inhaled fluticasone; ritonavir; toxicity.

Publication types

Case Reports

MeSH terms

Administration, Inhalation
Adrenal Cortex Hormones / administration & dosage
Adrenal Cortex Hormones / adverse effects*
Adrenal Cortex Hormones / therapeutic use
Adult
Androstadienes / administration & dosage
Androstadienes / adverse effects*
Drug Interactions
Fluticasone
HIV Infections / drug therapy*
HIV Protease Inhibitors / administration & dosage
HIV Protease Inhibitors / adverse effects*
Humans
Magnetic Resonance Imaging
Male
Osteonecrosis / chemically induced*
Osteonecrosis / drug therapy
Osteonecrosis / pathology
Ritonavir / administration & dosage
Ritonavir / adverse effects*
Treatment Outcome

Substances

Adrenal Cortex Hormones
Androstadienes
HIV Protease Inhibitors
Fluticasone
Ritonavir