Native valve right sided infective endocarditis

Eur J Intern Med. 2013 Sep;24(6):510-9. doi: 10.1016/j.ejim.2013.01.010. Epub 2013 Jan 28.

Abstract

Right-sided infective endocarditis (RSIE) accounts for 5-10% of all cases of infective endocarditis (IE), and is predominantly encountered in the injecting drug user (IDU) population, where HIV and HCV coinfections often coexist. Staphylococcus aureus is the most common pathogen. The pathogenesis of RSIE is still not well understood. RSIE usually presents as a persistent fever with respiratory symptoms whilst signs of systemic embolisation as seen in left-sided IE are notably absent. The prompt diagnosis of RSIE thus requires a high index of suspicion. Transthoracic echocardiography (TTE) can detect the majority of RSIE, whilst transoesophageal echocardiography (TOE) can increase sensitivity. Virulence of the causative organism and vegetation size are the major determinants of prognosis. Most cases of RSIE resolve with appropriate antibiotic administration.

Keywords: Endocarditis and HIV; Endocarditis in IDU; Pneumonic valve endocarditis; Right sided endocarditis; Tricuspid native valve endocarditis.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Coinfection
  • Echocardiography
  • Endocarditis, Bacterial / diagnosis
  • Endocarditis, Bacterial / drug therapy
  • Endocarditis, Bacterial / epidemiology*
  • HIV Infections / epidemiology*
  • Heart Valve Diseases / diagnosis
  • Heart Valve Diseases / drug therapy
  • Heart Valve Diseases / epidemiology*
  • Hepatitis C, Chronic / epidemiology*
  • Humans
  • Prognosis
  • Pulmonary Valve* / diagnostic imaging
  • Risk Factors
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / drug therapy
  • Staphylococcal Infections / epidemiology*
  • Staphylococcus aureus
  • Substance Abuse, Intravenous / epidemiology*
  • Tricuspid Valve* / diagnostic imaging

Substances

  • Anti-Bacterial Agents