Abstract
Kidney involvement is an under-recognized complication of both Hodgkin and non-Hodgkin lymphoma. The diversity of lymphoma-related renal manifestations makes diagnosis difficult. Although abrupt worsening of kidney function may be the first sign of malignant disease, renal effects can be subtle or even silent. The causes of renal involvement similarly are varied. We discuss a case of non-Hodgkin lymphoma and associated kidney failure from several distinct malignancy-related mechanisms and review the spectrum of lymphoma-related kidney involvement.
Copyright © 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Aged
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Antibodies, Monoclonal, Murine-Derived / therapeutic use
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Antineoplastic Agents / therapeutic use
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Boronic Acids / therapeutic use
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Bortezomib
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Dexamethasone / therapeutic use
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Drug Therapy, Combination
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Humans
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Kidney / pathology
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Kidney / physiopathology*
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Lymphoma, Non-Hodgkin / complications*
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Lymphoma, Non-Hodgkin / drug therapy
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Lymphoma, Non-Hodgkin / physiopathology*
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Male
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Prognosis
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Pyrazines / therapeutic use
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Renal Insufficiency / diagnosis
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Renal Insufficiency / etiology*
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Renal Insufficiency / physiopathology*
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Rituximab
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Treatment Outcome
Substances
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Antibodies, Monoclonal, Murine-Derived
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Antineoplastic Agents
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Boronic Acids
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Pyrazines
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Rituximab
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Bortezomib
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Dexamethasone