Abstract
We report a series of 9 patients, 6 men and 3 women, who presented nail hyperpigmentation arising between 6 and 24 months from the start of hydroxyurea therapy. The most commonly observed clinical pattern was that of longitudinal melanonychia. In only 1 patient, who was affected in all 20 nails, we observed longitudinal melanonychia, diffuse melanonychia, and hyperpigmentation of the skin.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Agents / adverse effects*
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Antineoplastic Agents / therapeutic use
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Cohort Studies
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Female
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Follow-Up Studies
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Hematologic Neoplasms / diagnosis
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Hematologic Neoplasms / drug therapy*
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Humans
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Hydroxyurea / adverse effects*
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Hydroxyurea / therapeutic use
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Hyperpigmentation / chemically induced*
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Hyperpigmentation / diagnosis
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Male
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Middle Aged
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Nail Diseases / chemically induced*
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Nail Diseases / diagnosis
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Risk Assessment
Substances
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Antineoplastic Agents
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Hydroxyurea