Abstract
We report a case of a 42-yr-old woman with Langerhans cell histiocytosis (LCH) confined to the thyroid and associated with lymphocytic thyroiditis and a papillary microcarcinoma. This patient remains free of symptoms 14 mo after surgery. Thyroid LCH is rare. In children, it usually occurs as part of a multisystemic disease, whereas it is usually exclusive in adults. Isolated thyroid LCH is frequently associated with another thyroid disease, especially lymphocytic thyroiditis, suggesting that it is a reactive process rather than a neoplastic proliferation. The prognosis of isolated thyroid LCH is good. However, because it can rarely precede or reveal a multisystemic disease, additional investigations as well as a prolonged follow-up are justified.
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Foulet-Rogé, A., Josselin, N., Guyetant, S. et al. Incidental langerhans cell histiocytosis of thyroid: Case report and review of the literature. Endocr Pathol 13, 227–233 (2002). https://doi.org/10.1385/EP:13:3:227
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DOI: https://doi.org/10.1385/EP:13:3:227