Journal of the American Academy of Dermatology
The sign of Leser-Trélat in a case of adenocarcinoma of the lung☆,☆☆
Section snippets
Case report
On October 22, 1997, a 58-year-old woman presented to her dermatologist because of a concern about the acute development of innumerable seborrheic keratoses over the trunk and proximal extremities. According to the patient, these lesions had developed rapidly over a period of a “few months.” She also complained of an even more recent development of brownish discoloration and thickening of the skin of the axillary and perianal areas characteristic of acanthosis nigricans and a slight thickening
Discussion
The sign of Leser-Trélat is the sudden development of a large number of seborrheic keratoses in association with a malignant neoplasm. Our report appears to be the first to demonstrate an association with adenocarcinoma of the lung. In a recent review of the sign of Leser-Trélat, Schwartz5 summarized the type of cancer and its site of origin in 86 patients with this sign. In 51 patients, the associated malignancy was an adenocarcinoma, most frequently involving the stomach, breast, and
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Leser-Trélat sign syndrome
2013, FMC Formacion Medica Continuada en Atencion PrimariaCutaneous paraneoplasia
2011, Clinics in DermatologyCitation Excerpt :It may occur in benign conditions as during pregnancy9 and in some benign tumors.7 Every patient with the Leser-Trélat sign should be evaluated for a hidden neoplasia.13 Histopathology is similar to the usual seborrheic keratoses.
Lentigo melanoma associated with Leser–Trélat syndrome
2022, Vestnik Dermatologii i VenerologiiHyperplasia-associated cutaneous paraneoplasia
2021, HautarztEruptive seborrheic keratosis: A perilous clue
2021, Cleveland Clinic Journal of MedicineParaneoplastic syndromes in cholangiocarcinoma
2020, World Journal of Hepatology
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This supplement is made possible through an educational grant from Ortho Dermatological to the American Academy of Dermatology.
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Reprint requests: Arnold L. Schroeter, Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.