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Anti-cardiolipin and Anti-β2-glycoprotein I Antibodies in Patients with Inflammatory Bowel Disease

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Abstract

Patients with inflammatory bowel disease (IBD)frequently suffer from thromboembolic events.Anti-cardiolipin (aCL) antibodies have been shown to beassociated with thrombosis. Recently, the antibodies against the anti-cardiolipin cofactorβ2-glycoprotein I(aβ2GPI) have been found with higherspecificity for thrombosis. The presence of theseantibodies was assessed in 128 patients with IBD [83 with ulcerative colitis (UC) and 45 withCrohn's disease (CD)] and 100 healthy controls (blooddonors). Patients with UC and CD had a significantlyhigher prevalence of aCL (18.1% and 15.6%, respectively) than healthy controls (HC) (3%). Eleven IBDpatients (8.6%) but no HC had aβ2GPI.None of the IBD patients with a history of thrombosishad aCL and only one of them (a UC patient with deepvein thrombosis of the right leg) had a high titer of IgGaβ2GPI. In conclusion, these data showthat both aCL and aβ2GPI aresignificantly associated with IBD but further studiesare needed to determine the significance of our findings.

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Authors
  1. I. E. Koutroubakis
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  2. E. Petinaki
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  3. E. Anagnostopoulou
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  4. H. Kritikos
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  5. I. A. Mouzas
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  6. E. A. Kouroumalis
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  7. O. N. Manousos
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Koutroubakis, I.E., Petinaki, E., Anagnostopoulou, E. et al. Anti-cardiolipin and Anti-β2-glycoprotein I Antibodies in Patients with Inflammatory Bowel Disease. Dig Dis Sci 43, 2507–2512 (1998). https://doi.org/10.1023/A:1026602803622

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