MALT lymphomaLong-term results of stomach-conserving therapy in gastric MALT lymphoma
Section snippets
Materials and methods
Between 1975 and 2002 115 patients with gastric MALT lymphoma stage I and II were treated in the Netherlands Cancer Institute.
Patients were staged according to the Ann Arbor classification system, modified by Musshoff [22] and according to the Paris staging system for primary gastrointestinal lymphomas [23] in 33 patients. Staging procedures included patients’ history and physical examination (including inspection of Waldeyer’s ring), complete blood count, erythrocyte sedimentation rate, serum
Clinical characteristics of overall population
The majority of patients presented with stage I, H. pylori positive disease. Detailed information on the clinical characteristics of all patients is given in Table 1.
Treatment and response
Fig. 1 summarizes the treatment of all evaluated patients (n = 115). In order to analyze the effects of radio- and/or chemotherapy without influence of H. pylori eradication, patients who have received H. pylori eradication at any moment in time were described separately. Before the introduction of H. pylori eradication, patients
Discussion
This paper describes a large single institution series of patients with primary gastric MALT lymphoma treated with stomach-conserving therapy. It reflects the changes in therapeutic approach over the last decades. From the 1970s to the early 1990s the majority of patients with stage I gastric MALT lymphoma were treated with radiotherapy alone. This resulted in a CR-rate of 96%, a low recurrence rate and an excellent long-term (cancer-specific) survival. From 1994 onwards, most of these patients
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