Basic and patient-oriented researchAcinic Cell Carcinoma of Minor Salivary Glands: A Clinical and Immunohistochemical Study
Section snippets
Materials and Methods
In this study we describe 11 cases of ACC of minor salivary glands. The patients presented to our clinic at the “G. Papanikolaou” Hospital at Thessaloniki for further treatment of their disease. The patients were 7 women and 4 men. The patients' age ranged from 46 to 83 years. The distribution of the primary sites were: buccal mucosa (4), maxilla/maxillary sinus, etc (2), hard palate (1), junction of hard and soft palate (1), lower lip (1), labiomarginal sulcus (1), and vestibular sulcus and
Results
Mean follow-up ranged from 2 to 15 years. Of the 11 patients, 7 are alive 2, 3, 4, 5, and 15 years after the initial therapy. Two patients died of other causes free of the disease 9 and 10 years after the initial treatment, and 2 patients died of the disease (local recurrence, distant metastases 2 and 3 years later). Results of the therapeutic procedures and follow-up of the patients are analyzed in Table 1. Results of the analysis of immunohistochemical markers (ki-67, p53, c-erbB-2/new and
Discussion
Acinic cell carcinoma is histologically defined as a tumor with predominant differentiation toward serous acinar cells, variably admixed with clear, vacuolated, and intercalated ductal cells.2, 3, 6, 15 The morphological growth patterns are: solid, microcystic, papillary-cystic, and follicular. The solid and microcystic ones are the most common patterns.1, 2, 3, 16 Acinar cells are large, polygonal cells with lightly basophilic, granular cytoplasm and round, eccentric nuclei (Fig 2A). The
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Acinic cell carcinoma of parotid gland
2023, Radiology Case ReportsPrimary acinic cell carcinoma of mandible, report of a case and literature review
2021, International Journal of Surgery Case ReportsCitation Excerpt :ACC is a tumor with predominant differentiation in serous acinar cells, which most frequently occurs in the parotid gland (>83%) followed by submandibular glands, minor salivary glands, and sublingual glands. Furthermore, some unusual regions including the palate, mandible, nose, and paranasal sinuses could be affected [4,5]. the tumor is mainly composed of serous acinar cells variably admixed with clear, vacuolated, and intercalated ductal cells characterized by four variable patterns; solid, microcystic, papillary cystic (associated with hemorrhage), and follicular.
Acinic cell carcinoma arising in minor salivary gland of the upper lip
2017, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :Additionally, some reports have indicated a relationship between histological growth patterns and prognosis; thus the microcystic pattern and intercalated-duct cell types were slightly more frequent in tumors that resulted in death of the patients [5] and the papillary-cystic pattern had a very poor prognosis [22]. It has been reported that a Ki-67 labeling index of over 10% of the tumor cells indicates high proliferative activity and is associated with a poor prognosis [19]. In our case, we observed a papillary-cystic growth pattern and a Ki-67 labeling index of approximately 10%.
Diagnostic Pathology: Head & Neck
2017, Diagnostic Pathology: Head and NeckAcinic cell carcinoma arising in the buccal mucosa: A case report of specific type of papillary-cystic variant
2014, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyA case of acinic cell carcinoma arising in the lower lip
2013, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :On the other hand, Lewis et al. reported that there was no correlation between cell type or morphologic pattern and disease progression [30]. Triantafillidou et al. reported that there were no histopathological features that predict the prognosis of acinic cell carcinoma, and that the expression of Ki-67 and p53 in >10% of cells was associated with a poor prognosis [31]. Overall, tumors with infiltrative growth should be the most aggressive with the worst prognosis [1,2,32].