Oral Sarcoidosis: Report of a Case and Review of Literature

doi:10.1016/j.joms.2005.09.028

Journal of Oral and Maxillofacial Surgery

Volume 65, Issue 6, June 2007, Pages 1256-1259

https://doi.org/10.1016/j.joms.2005.09.028 Get rights and content

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Report of a Case

In January 2001, a 71-year-old Japanese woman was referred to our Oral and Maxillofacial Surgery Clinic (Kimitsu Chuo Hospital, Chiba, Japan) for evaluation and treatment of a nodular lesion on the right buccal submucosa that she had first noticed 2 weeks previously. The lesion was painless and showed no growth during this period. Her medical history revealed that she suffered from systemic sarcoidosis with BHL and histologically diagnosed skin sarcoidosis of the right lower eyelid (Fig 1); she

Discussion

Sarcoidosis is a chronic disease consisting of multiple granulomas of the skin, mucosal surfaces, salivary glands, lungs, and occasionally other major organs. In the head and neck region, the most predominant site of sarcoidosis is the parotid glands or cervical lymph nodes, which are characterized by firm painless enlargement.² Intraoral presentation of sarcoidosis is less frequently encountered, although precise incidence data are not available. In this study, we could find 23 well-documented

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References (21)

M.J. Steinberg et al.
Treating oral sarcoidosis
J Am Dent Assoc
(1994)
J. Hildebrand et al.
Sarcoidosis: Report of two cases with oral involvement
Oral Surg Oral Med Oral Pathol
(1990)
A.C. Van Maarsseveen et al.
Oral involvement in sarcoidosis
Int J Oral Surg
(1982)
A. Piattelli et al.
Oral ulceration as a presenting sign of unknown sarcoidosis mimicking a tumor: Report of 2 cases
Oral Oncology
(1998)
D. Blinder et al.
Oral manifestation of sarcoidosis
Oral Surg Oral Med Oral Pathol
(1997)
D.M. DeLuke et al.
Oral manifestations of sarcoidosis: Report of a case masquerading as a neoplasm
Oral Surg Oral Med Oral Pathol
(1985)
R.I. MacLeod et al.
Sarcoidosis of the tongue: A case report
Br J Oral Maxillofac Surg
(1985)
L.S. Newman et al.
Sarcoidosis
N Engl J Med
(1997)
B. Hussman et al.
Sarcoidosis: Medical and dental implications
Oral Surg Oral Med Oral Pathol
(1999)
S. Soto et al.
Oral sarcoidosis with tongue involvement
Oral Surg Oral Med Oral Pathol
(1997)

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Cited by (30)

Multiple nodules of the oral mucosa
2020, Journal of Stomatology, Oral and Maxillofacial Surgery
Citation Excerpt :
To the best of the authors’ knowledge, this is the first case report showing quality images of the oral lesions. Nevertheless, Kasamatsu et al. reported that 58% of patients with established sarcoidosis presented noncaseating granulomas on the lip mucosa diagnosed on minor salivary gland biopsy [4]. In this case, all lesions were removed because of the discomfort they caused, and the tissue was strengthened with free gingival grafts combined with periodontal treatment around the implants.
Cutaneous manifestations of sarcoidosis
2016, Annales de Dermatologie et de Venereologie
La sarcoïdose est une affection systémique granulomateuse d’étiologie inconnue. Ses manifestations dermatologiques sont très polymorphes. Elles sont classiquement séparées en lésions spécifiques, car formées de granulomes, d’évolution le plus souvent chronique ; et en lésions non spécifiques, principalement l’érythème noueux d’évolution aiguë. Elles s’observent approximativement chez 25 % des patients atteints de sarcoïdose. L’atteinte cutanée peut être inaugurale. Le diagnostic de sarcoïdose cutanée confronte le clinicien à trois problèmes : la recherche d’une localisation viscérale de la maladie, l’évaluation du pronostic, la prise en charge au long cours associant une surveillance régulière et, en cas de gêne esthétique ou fonctionnelle, un traitement.
Sarcoidosis is a systemic granulomatous disorder of unknown aetiology. Its dermatological manifestations are extremely polymorphous. They are normally classed as either specific lesions, comprising granulomas, which are generally chronic, or non-specific lesions, principally acute erythema nodosum. These signs are seen in around 25% of sarcoidosis patients. The disease may be heralded by a skin disorder. Diagnosis of cutaneous sarcoidosis provides the clinician with three problems: screening for a visceral site of the disease, determination of the prognosis, and long-term management with regular monitoring coupled with suitable therapy in the event of cosmetic or functional impairment.
Cutaneous Sarcoidosis
2015, Clinics in Chest Medicine
Citation Excerpt :
Any portion of the oral cavity can be affected, and this can be the presenting sign of systemic disease.102 Within the oral cavity, the buccal mucosa, gingiva, lips, tongue, and floor of mouth were most commonly affected, followed by the palate and submandibular glands.103 Genital involvement in sarcoidosis also is rare and can present as infiltrative plaques, nodules, masses, or swelling in these areas.104–108
Sarcoidosis
2015, Dermatologic Clinics
Citation Excerpt :
Sarcoidosis may involve the oral, nasal, and genital mucosa. Granulomatous lesions, usually papules or papulonodules, develop on any part of the oral mucosa and presentations vary from infiltrated papules to firm nodules to ulcers (Fig. 10).89,90 Anogenital sarcoidosis, although rare, may manifest with tender indurated papules and nodules, pruritic scaly plaques, or swelling.91–94
Skin manifestations of sarcoidosis
2012, Presse Medicale
Citation Excerpt :
Finally, the development of oedema in the lower extremities, generally one-sided, can also be a rare specific manifestation of sarcoidosis [109]. Oral lesions are infrequent in sarcoidosis [110,111]. A recent review of the English-language literature detected only 47 patients with lesions in the soft tissue of the oral cavity [110].
The skin manifestations of sarcoidosis are classified as specific, where biopsy reveals non-caseating granulomas, and non-specific, typically erythema nodosum. The most frequent specific (granulomatous) skin lesions are maculopapules, subcutaneous nodules, scar sarcoidosis, plaques and lupus pernio. Skin biopsy allows early diagnosis of sarcoidosis through a non-aggressive procedure. In sarcoidosis, erythema nodosum is usually associated with bilateral hilar lymphadenopathy on the chest radiograph, this being known as Löfgren's syndrome. Cutaneous lesions have prognostic significance. Löfgren's syndrome is usually associated with good prognosis and spontaneous resolution. Maculopapular lesions and subcutaneous nodules are more often associated with remission of the systemic disease at two years, while plaques and, mainly, lupus pernio are hallmarks of chronic disease. Most cutaneous lesions of sarcoidosis are only mildly symptomatic and do not require treatment. However, chronic skin lesions, particularly lupus pernio, are disfiguring and can have a strong psychological and social impact. Treatment of these lesions is a challenge since they do not respond well to conventional treatments. The introduction of biological agents has been an important although not definitive advance in the treatment of cutaneous sarcoidosis.
Sarcoidosis - A review article
2022, Journal of Oral and Maxillofacial Pathology

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Case reportOral Sarcoidosis: Report of a Case and Review of Literature

Section snippets

Report of a Case

Discussion

First page preview

J Am Dent Assoc

Oral Surg Oral Med Oral Pathol

Int J Oral Surg

Oral Oncology

Oral Surg Oral Med Oral Pathol

Oral Surg Oral Med Oral Pathol

Br J Oral Maxillofac Surg

Sarcoidosis

N Engl J Med

Sarcoidosis: Medical and dental implications

Oral Surg Oral Med Oral Pathol

Oral sarcoidosis with tongue involvement

Oral Surg Oral Med Oral Pathol

Case report
Oral Sarcoidosis: Report of a Case and Review of Literature