Solitary Orbital Infantile Myofibroma: A Case Report and Review of the Literature

doi:10.1016/j.jaapos.2005.11.012

Journal of American Association for Pediatric Ophthalmology and Strabismus

Volume 10, Issue 3, June 2006, Pages 283-284

https://doi.org/10.1016/j.jaapos.2005.11.012 Get rights and content

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Case report

A healthy, 29-month-old boy presented with proptosis, which his mother first noted 10 days previously, that seemed to be worsening. Examination verified 3 mm of left proptosis and 2 mm of downward displacement of the left eye. Visual acuity, extraocular motility, and pupillary function were normal. The anterior and posterior segments were visualized well and appeared healthy. Computed tomography of the orbits revealed a 2.8 × 2.5 × 2.2-cm mass centered in the greater wing of the left sphenoid

Discussion

Infantile myofibromatosis is a rare fibrous tumor of childhood and infancy. The family of fibrous tumors of childhood includes fibrous hamartoma of infancy, infantile digital fibromatosis, fibromatosis colli, infantile (desmoid) fibromatosis, hyaline fibromatosis, gingival fibromatosis, and calcifying aponeurotic fibroma.¹ In Chung’s 1981 series, one-third occurred in the head and neck, and most were solitary lesions with good prognosis with or without excision. However, 3 of the 28 patients

References (9)

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Orbital and periorbital myofibromas in childhood two case reports
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Infantile myofibromatosis of orbital bone a case report with computed tomography magnetic resonance imaging, and histologic findings
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periorbital solitary-type infantile myofibromatosis
J Pediatr Ophthalmol Strabismus
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There are more references available in the full text version of this article.

Cited by (14)

Solitary adult orbital myofibroma: Report of a case and review of the literature
2020, American Journal of Ophthalmology Case Reports
Citation Excerpt :
The head and neck is the most common anatomic sub-region involved by myofibroma and the tumor is mainly seen in infancy and childhood. There are several case reports and series of infantile/childhood orbital myofibroma5–19 and involvement of periocular soft tissues.20–22 However, though myofibroma is the most common fibrous tumor of infancy, the tumor remains rare in the orbit.
Myofibromas are benign soft tissue tumors commonly encountered in infancy and childhood. Developing usually within the first two years of life, they can be multicentric and involve deep visceral organs.
We present the rare occurrence of a solitary orbital myofibroma in an adult patient. The clinical, histopathologic and immunohistochemical findings of the tumor are documented.
A comprehensive review of pediatric and adult orbital and periocular involvement by myofibroma is presented. Its characteristic pathologic and molecular findings are reviewed.
Myofibromas are uncommon but important tumors that can occur in the head and neck region, including the orbit. Seen more often in children, they can rarely be encountered in adult patients. Diagnosis is possible with a panel of immunostains and molecular analysis can be further confirmatory.
Extended Endonasal Endoscopic Complete Resection of a Solitary Intraorbital Myofibroma: A Case Report and Literature Review
2020, World Neurosurgery
Citation Excerpt :
Persaud et al.13 reported a case of a 29-month-old boy who presented with ptosis found to have a myofibroma centered in the greater wing of the left sphenoid bone with bony erosion extending posteriorly into the middle cranial fossa. The tumor was excised completely via a left frontal craniotomy.13 In their literature review,13 these authors tracked only 9 cases of infantile myofibromas involving the orbit.3,17-23
Infantile myofibromatosis is a rare benign disease of mesenchymal origin. It occurs mostly in infants but can occur in children and adults. It presents in 2 forms: solitary and multicentric. The presence of an orbital component, whether as a solitary lesion or as part of the multicentric disease, is even rarer. Surgery is required when these tumors behave aggressively and grow rapidly or when they are large enough to cause compression symptoms. Several surgical approaches have been described to resect such lesions.
We present a case of a solitary intraorbital myofibroma extending into the optic canal in a 6-year-old girl that was completely resected via an extended endonasal endoscopic approach.
This case report highlights the advantages of the extended endonasal endoscopic approach in terms of intraoperative and postoperative factors.
A rare erosive orbital mass in a child: Case report of myofibroma
2017, Journal of Current Ophthalmology
Citation Excerpt :
Myofibromas predominantly involve the skin and superficial soft tissue of the head and neck in children especially those younger than two year old.1 While it rarely involves the ocular region, myofibroma primarily occurs in the extra orbital region and can be with or without bone invasion.2,3 Imaging findings on this tumor lack specificity and the diagnosis has been mainly based on histologic and histochemical inputs.1,2,4
To present the clinical, histological, and radiographic findings of a case of orbital myofibroma in an unusual location. The literature is reviewed and the clinical relevance discussed.
A 5-year-old boy was examined with a 1.5-month history of progressive swelling in the left supraorbital region.
Examination revealed a firm, painless mass in the supralateral region of the left orbit with slight reddish discoloration of the overlying skin. Computerized tomography (CT) scan images showed a well demarcated, homogenous, solid mass with extension to the lacrimal gland region and adjacent to frontal bone erosion. The mass was surgically excised and was confirmed to be myofibroma in diagnostic histological studies. There has been no evidence of recurrence in the first year after surgery.
Clinical appearance and imaging findings are unspecific for this tumor, and histological examination still remains the definite method of diagnosis. Therefore, it is important to be able to differentiate myofibromas from other malignant tumors with a similar presentation in pediatric patients to avoid mismanagement.
Mesenchymal, Fibroosseous, and Cartilaginous Orbital Tumors
2022, Albert and Jakobiec's Principles and Practice of Ophthalmology: Fourth Edition
Solitary orbital myofibroma in a child: A rare case report with literature review
2019, Indian Journal of Ophthalmology
Mandibular swelling in a 5-year-old child - Mandibular myofibroma
2014, BMJ Case Reports

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Short reportSolitary Orbital Infantile Myofibroma: A Case Report and Review of the Literature

Section snippets

Case report

Discussion

Ophthalmology

Ophthalmology

Infantile myofibromatosis

Cancer

periorbital solitary-type infantile myofibromatosis

J Pediatr Ophthalmol Strabismus

Short report
Solitary Orbital Infantile Myofibroma: A Case Report and Review of the Literature