Biochimica et Biophysica Acta (BBA) - Biomembranes
ReviewBand 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context☆,☆☆
Graphical abstract
Human Band 3 dimer in a lipid bilayer. Each subunit is colored using the rainbow color (blue to red) from N-terminal to C-terminal and the positions of the lipid phosphate groups shown as gray spheres.
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This article is dedicated to the (great) grandfathers in the Band 3 field: mentor Guido Guidotti, Bob Gunn, Harvey Lodish, Hermann Passow, Aser Rothstein, Ted Steck, and Michael Tanner who all inspired future generations of scientists including colleagues Seth Alper, Lesley Bruce, Naotaka Hamasaki, Mike Jennings, Phil Knauf, Ron Kopito, Phil Low, Jim Salhany, Ashley Toye, and others to devote their continued interest to this membrane transport glycoprotein with such a poor name.
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For the purpose of this review, Band 3 refers to the native protein as found in red blood cells, AE1 to the protein expressed from its cDNA, SLC4A1 as the gene and SLC4A1 as the gene product.