Allergic Nephropathy Associated With Ciprofloxacin
Section snippets
REPORT OF CASE
A 78-year-old man with extensive open injuries of the face and head was admitted to the trauma center at our institution after a large tractor tire had exploded during accidental overinflation. An emergency surgical procedure was done for repair of sinus fractures, facial fractures, an open-skull fracture, complex facial lacerations, and a hemorrhagic right ocular globe and for decompression and repair of the macerated brain and meninges.
Because of postoperative fever and the probability of
DISCUSSION
We believe that this patient's acute renal failure was due to an allergic tubulointerstitial nephritis. The presence of rapid-onset azotemia, peripheral blood eosinophilia, and eosinophiluria supports this diagnosis.5, 6 The only medications being used by the patient at that time were ciprofloxacin, ranitidine, and phenytoin. Ranitidine has not been reported to cause allergic tubulointerstitial nephritis. The fact that the patient was rechallenged with famotidine, which is structurally similar
CONCLUSION
This case should serve notice to clinicians that ciprofloxacin can rarely cause allergic tubulointerstitial nephritis. This diagnosis should be considered if azotemia is detected during treatment with ciprofloxacin.
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Cited by (27)
Is ciprofloxacin safe in patients with solitary kidney and upper urinary tract infection?
2016, Biomedicine and PharmacotherapyCitation Excerpt :acute interstitial nephritis associated with auto-immune haemolytic anaemia; in this case interstitial nephritis became chronic, requiring dialysis [20] allergic acute interstitial nephritis; Rastogi reports a case that evolved favourably at discontinuation of ciprofloxacin and therapy with corticosteroids [21]. acute renal failure secondary to oral ciprofloxacin therapy; Hootkins et al. report a case that presented eosinophilia, suggesting a reaction of hypersensitivity [22]
Myoglobin-associated acute kidney injury in the setting of ciprofloxacin administration
2012, American Journal of Kidney DiseasesCitation Excerpt :Fluoroquinolone antibiotics, including ciprofloxacin, are a group of synthetic derivatives of the parent compound nalidixic acid that exert bacteriocidal effects by inhibiting bacterial DNA gyrase and topoisomerase IV. Ciprofloxacin and other fluoroquinolones have been reported to trigger AKI by inducing acute interstitial nephritis and, rarely, crystal nephropathy, thrombotic microangiopathy, and tubular necrosis and apoptosis at supratherapeutic dosage.6,8-10 Fluoroquinolones also are known to cause a spectrum of musculoskeletal complications involving tendon, cartilage, bone, and muscle (reviewed in4).
Fluoroquinolone induced acute renal failure. General review about a case report with crystalluria due to ciprofloxacin
2005, Nephrologie et TherapeutiqueRenal vasculitis associated with ciprofloxacin
1995, American Journal of Kidney DiseasesReversible Renal Failure Due to IgA Nephropathy Associated With Osteomyelitis
1992, American Journal of Kidney Diseases
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