Elsevier

The Journal of Pediatrics

Volume 90, Issue 2, February 1977, Pages 236-240
The Journal of Pediatrics

Original article
Hypomelanosis of Ito (incontinentia pigmenti achromians): A neurocutaneous syndrome

https://doi.org/10.1016/S0022-3476(77)80636-7Get rights and content

Hypomelanosis of Ito (incontinentia pigmenti achromians, systematized achromic nevus) is a cutaneous abnormality consisting of bizarre, patterned, macular hypopigmentation over variable portions of the body surface. Multiple associated defects in other systems occur in a significant percentage of affected individuals. Most commonly, the central nervous system, eye, and musculoskeletal structures are involved. It is suggested that the cutaneous abnormality, which is often defectable at birth or during infancy, may forewarn pediatricians of the possible emergence of defects in other organ systems.

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