Original ArticlesViral causes of the acute retinal necrosis syndrome
Section snippets
Methods
All patients with a diagnosis of acute retinal necrosis syndrome, based on the characteristic clinical criteria described by the Executive Committee of the American Uveitis Society,2 from whom undiluted vitreous and aqueous specimens were received for diagnostic evaluation from December 1993 to July 1998, were included. The clinical criteria described by the American Uveitis Society for the diagnosis of acute retinal necrosis syndrome include the findings of focal, well-demarcated areas of
Results
Laboratory results and clinical histories were analyzed from 28 patients (30 eyes) diagnosed with acute retinal necrosis syndrome from whom vitreous and aqueous biopsy specimens were received for diagnostic evaluation using polymerase chain reaction–based assays. Cytomegalovirus, varicella-zoster virus, or herpes simplex virus DNA was detected in 29 of 30 eyes. No sample was positive for DNA from more than one virus.
Varicella-zoster virus DNA was detected in 12 vitreous and six aqueous
Discussion
In this retrospective study, we reviewed the laboratory results and clinical histories of 28 patients (30 eyes) diagnosed with acute retinal necrosis syndrome, from whom either vitreous or aqueous specimens were analyzed by polymerase chain reaction–based assays for the detection of viral DNA. Varicella-zoster virus DNA was detected in the vitreous or aqueous of 13 patients (15 eyes); the median age at the time of infection was 57 years (mean age, 52.7 years). Herpes simplex type 1 virus DNA
References (35)
Standard diagnostic criteria for the acute retinal necrosis syndrome
Am J Ophthalmol
(1994)- et al.
The acute retinal necrosis syndromehistopathology and etiology
Ophthalmology
(1982) - et al.
Demonstration of herpes group virus in acute retinal necrosis syndrome
Am J Ophthalmol
(1986) - et al.
Rapidly progressive acute retinal necrosis secondary to herpes simplex virus, type 1
Ophthalmology
(1990) - et al.
Varicella-zoster virus is a cause of the acute retinal necrosis syndrome
Ophthalmology
(1986) - et al.
Serologic and polymerase chain reaction analysis of intraocular fluids in the diagnosis of infectious uveitis
Am J Ophthalmol
(1996) - et al.
Acute retinal necrosis syndrome presenting with papillitis and arcuate neuroretinitis
Ophthalmology
(1988) - et al.
Herpesvirus antibody levels in the etiologic diagnosis of the acute retinal necrosis syndrome
Am J Ophthalmol
(1992) - et al.
Detection of intraocular antibody production to herpes viruses in acute retinal necrosis syndrome
Am J Ophthalmol
(1994) - et al.
Diagnosis and management of the acute retinal necrosis syndrome
Surv Ophthalmol
(1991)
Acute retinal necrosis following herpes zoster dermatitis
Ophthalmology
Association of varicella-zoster dermatitis with ARN syndrome
Ophthalmology
Acute retinal necrosis caused by reactivation of herpes simplex virus type 2
Am J Ophthalmol
Cytomegalovirus-associated acute retinal necrosis syndrome
Am J Ophthalmol
A sensitive and specific polymerase chain reaction–based assay for the diagnosis of cytomegalovirus retinitis
Am J Ophthalmol
A polymerase chain reaction–based assay for the diagnosis of varicella-zoster virus retinitis in patients with AIDS
Am J Ophthalmol
Disciform keratitisa case of herpes zoster sine herpete
Am J Ophthalmol
Cited by (274)
Causes of infectious pediatric uveitis: A review
2024, Survey of OphthalmologyThe novel role of lymphatic vessels in the pathogenesis of ocular diseases
2023, Progress in Retinal and Eye ResearchViral Retinitis
2023, Advances in Ophthalmology and OptometryAn atypical case of viral panuveitis and retinal vasculitis with retrograde extension associated with human herpesvirus-6
2022, American Journal of Ophthalmology Case ReportsAcute retinal necrosis caused by herpes simplex type 2
2022, Medicina Clinica