Brief reportAn experimental model examining the role of magnesium in the therapy of acute myocardial infarction
Reference (6)
- et al.
Intravenous magnesium sulfate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2)
Lancet
(1992) - et al.
Magnesium therapy and mortality in acute myocardial infarction
Am J Cardiol
(1990) ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarctions
Lancet
(1995)
Cited by (45)
The importance of effect mechanism in the design and interpretation of clinical trials: The role of magnesium in acute myocardial infarction
2002, Progress in Cardiovascular DiseasesPro: Magnesium should be administered to all coronary artery bypass graft surgery patients undergoing cardiopulmonary bypass
2000, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :The use of magnesium before surgically induced myocardial ischemia, during myocardial ischemia, or at the time of myocardial reperfusion appears to improve postischemic mechanical recovery. Magnesium administered after myocardial reperfusion has begun does not improve postischemic mechanical recovery (Fig 1).5,7,14,19,20 Impact of timing of administration of magnesium on infarct size reduction. (
Postoperative atrial tachyarrhythmias in patients undergoing coronary artery bypass graft surgery without cardiopulmonary bypass: A role for intraoperative magnesium supplementation
2000, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :The prolonged benefit of magnesium administration may be due to the slow equilibrium of magnesium across tissues as well as the long half-life of >40 days.20,25 From the literature, it is unclear what is the optimal dose of magnesium supplementation; however, it does seem that in medical and surgical patients, the timing of administration may be important.10,11,17-22 One problem in the assessment of therapeutic effects of magnesium is the absence of a reliable and readily available monitor for intracellular magnesium levels.20,25
A randomized study of intravenous magnesium in acute myocardial infarction treated with direct coronary angioplasty
2000, American Heart JournalCitation Excerpt :Some potential limitations of the study should be acknowledged. First, although a 30% reduction in infarct size had been demonstrated in animals treated with early magnesium,1-4 the choice of a 30% reduction in 30-day mean IZWMSI as the primary end point was ultimately arbitrary because it is uncertain whether animal data can be directly transferred to the human setting and the direct measurement of infarct size in animals is clearly different from the echocardiographic evaluation of IZWMSI in humans. Second, because the sample size was dimensioned to test for a 30% reduction in the 30-day mean IZWMSI, the study had limited power to detect lower reductions and we cannot exclude the possibility that a larger study group might have shown a positive effect of magnesium administration.
Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits
2002, Cardiovascular ResearchLocalization of Chromosomal Regions Determining Magnesium and Calcium Content in Rice Varieties
2023, Russian Journal of Genetics
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Dr. Kloner's address is: The Heart Institute, Good Samaritan Hospital, 616 South Witmer Street, Los Angeles, California 90017.