Brief report
An experimental model examining the role of magnesium in the therapy of acute myocardial infarction

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Abstract

In conclusion, considering the results from our model, magnesium infusion is effective as adjunct therapy to enhance myocardial salvage in the setting of acute myocardial infarction. However, its effectiveness may be limited to a subset of patients whose magnesium therapy can be started early and combined with early reperfusion therapy.

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    Some potential limitations of the study should be acknowledged. First, although a 30% reduction in infarct size had been demonstrated in animals treated with early magnesium,1-4 the choice of a 30% reduction in 30-day mean IZWMSI as the primary end point was ultimately arbitrary because it is uncertain whether animal data can be directly transferred to the human setting and the direct measurement of infarct size in animals is clearly different from the echocardiographic evaluation of IZWMSI in humans. Second, because the sample size was dimensioned to test for a 30% reduction in the 30-day mean IZWMSI, the study had limited power to detect lower reductions and we cannot exclude the possibility that a larger study group might have shown a positive effect of magnesium administration.

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Dr. Kloner's address is: The Heart Institute, Good Samaritan Hospital, 616 South Witmer Street, Los Angeles, California 90017.

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