Amiodarone toxicity: Myopathy and neuropathy
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Cited by (51)
Treatment and Management of Infectious, Granulomatous, and Toxic Neuromuscular Disorders
2021, Neuromuscular Disorders: Treatment and ManagementA pattern-based approach to the interpretation of skeletal muscle biopsies
2019, Modern PathologyDrug induced myopathies
2017, Toxicologie Analytique et CliniqueEffects of chronic amiodarone treatment on rat testis
2016, Acta HistochemicaCitation Excerpt :The authors reported vacuolization of the Schwann cell cytoplasm, perineural inflammatory cell infiltration, demyelination, cellular degeneration. In another study that examined deltoid muscle specimens in a patient with amiodarone-induced myopathy, Fernando Roth et al. reported severe vacuolar myopathy presenting with small vacuoles in the muscle fibers and cellular swelling (Fernando Roth et al., 1990). Similar findings are also available for the thyroid gland (Nakazawa et al., 2008).
Toxic myopathies
2014, Neurologic ClinicsCitation Excerpt :The myopathy is usually not as severe as seen in chloroquine and vacuoles are less prominent on routine light microscopy, but EM still usually demonstrates abnormal accumulation of myeloid and curvilinear bodies. Amiodarone is an antiarrhythmic medication that may cause a tremor or ataxia and neuromyopathy.39,40 The neuromyopathy is characterized by severe proximal and distal weakness along with distal sensory loss and reduced muscle stretch reflexes.
Neurologic complications of arrhythmia treatment
2014, Handbook of Clinical Neurology
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From the Departments of Medicine, Pathology, and Neurology, University of California at Los Angeles School of Medicine; and the Division of Cardiology, Department of Medicine, Harbor-UCLA Medical Center.