Elsevier

Survey of Ophthalmology

Volume 28, Issue 4, January–February 1984, Pages 293-322
Survey of Ophthalmology

Review
Keratoconus and related noninflammatory corneal thinning disorders

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Abstract

Keratoconus and other noninflammatory corneal thinning disordes (keratoglobus, pellucid marginal degeneration and posterior keratoconus) are characterized by progressive corneal thinning, protrusion and scarring; the result is distorted and decreased vision. The etiology and pathogenesis of these disorders are unknown but may be associated with a variety of factors, including contact lens wear, eye rubbing, Down's syndrome, atopic disease, connective tissue disease, tapetoretinal degeneration and inheritance. Recent advances in techniques for biochemical and pathological investigation are now allowing further exploration in these areas. Early diagnosis is aided by the finding of irregular corneal astigmatism with inferior corneal steepening. Treatment ranges from simple spectacle correction to keratoplasty. In this review, the past and present literature on corneal thinning disorders is reviewed and practical approaches to diagnosis and management are outlined

References (261)

  • C.S. Foster et al.

    Ocular rigidity in keratoconus

    Am J Ophthalmol

    (1978)
  • M.A. Galin et al.

    Atopy and keratoconus

    Am J Ophthalmol

    (1958)
  • A.R. Gasset et al.

    Hard contact lens wear as an environmental risk in keratoconus

    Am J Ophthalmol

    (1978)
  • A.R. Gasset et al.

    Thermokeratoplasty in the treatment of keratoconus

    Am J Ophthalmol

    (1975)
  • H.L. Gould

    Management of keratoconus with corneal and scleral lenses

    Am J Ophthalmol

    (1970)
  • W.R. Haney et al.

    The occurrence of congenital keratoconus posticus circumscriptus in two siblings presenting a previously unrecognized syndrome

    Am J Ophthalmol

    (1961)
  • C.H. Alstrom et al.

    Heredo-retinopathia congenitalis. Monohybride recessiva autosomalis

    Hereditas Genetiskt Arkiv

    (1957)
  • M Amsler

    Frühdiognose und Mikrosymptome

    Ophthalmologica

    (1965)
  • M Amsler

    Le kératocône fruste au javal

    Ophthalmologica

    (1938)
  • M Amsler

    Quelques données du problème

    Bull Soc Belge Ophthalmol

    (1961)
  • A Anseth

    Keratoplasty for keratoconus

    Acta Ophthalmol

    (1967)
  • A Anseth et al.

    The importance of the polysaccharides for the normal function of the corneal stroma

    Acta Ophthalmol

    (1970)
  • A Anseth et al.

    Surgical treatment of corneal disorders

    Acta Ophthalmol

    (1971)
  • A Appelbaum

    Keratoconus

    Arch Ophthalmol

    (1936)
  • M.M. Appelmans et al.

    Kératocône aigu chez le mongoloïde

    Bull Soc Belge Ophthalmol

    (1961)
  • J.V. Aquavella et al.

    Thermokeratoplasty in the treatment of persistent corneal hydrops

    Arch Ophthalmol

    (1977)
  • J.V. Aquavella et al.

    Alterations in corneal morphology following thermokeratoplasty

    Arch Ophthalmol

    (1976)
  • J.J. Arentsen et al.

    Histopathologic changes after thermokeratoplasty for keratoconus

    Invest Ophthalmol Vis Sci

    (1977)
  • W Arkin

    Blue scleras with keratoglobus

    Am J Ophthalmol

    (1963)
  • M.G. Austin et al.

    Marfan's syndrome, with unusual blood vessel manifestations

    Arch Pathol

    (1957)
  • J.A. Baldone

    Optical experiences

    Trans Am Acad Ophthalmol Otolaryngol

    (1974)
  • W.E. Barry et al.

    Keratoconus in USAF flying personnel

    Aerospace Med

    (1972)
  • J Barth

    Statistiches Über 300 Keratokonusfálle Mit 557 befallen Augen

  • E.S. Bereston et al.

    Keratoconus associated with atopic dermatitis. Report of two cases

    Arch Dermat Syph

    (1942)
  • T Beretelson et al.

    Irreversible mydriasis following keratoplasty in keratoconus

    Acta Ophthalmol (Suppl) (Kblt)

    (1975)
  • G.B. Bietti et al.

    Sull'analisi statistica dill' associazione di malattie oculari

    Boll Ocul

    (1962)
  • G.B. Bietti et al.

    Sur l'association du kératocône avec le catarrhe printanier et sur son evidence statistique

    Bull Mem Soc Fr Ophthalmol

    (1958)
  • M Blagojevic et al.

    HLA antigens and keratoconus

  • H Bleckman et al.

    Studies on the glycosaminoglycan metabolism of cultured fibroblasts from human keratoconus corneas

    Exp Eye Res

    (1980)
  • S.A. Boruchoff et al.

    Comparison of suturing techniques in keratoplasty for keratoconus

    Ann Ophthalmol

    (1975)
  • B Bowden

    Keratoconus, keratoplasty and iris atrophy

    Trans Ophthalmol Soc Aust NZ

    (1966)
  • H.R. Brady

    Keratoconus development in a contact lens wearer

    Contact Lens Med Bull

    (1972)
  • S Brenner et al.

    Jadassohn-type anetoderma in association with keratoconus and cataract

    Ophthalmologica

    (1977)
  • F.S. Brightbill et al.

    Previous hard contact lens wear in keratoconus

    Contact Lens

    (1979)
  • A.J. Bron et al.

    Fibrillary lines of the cornea. A clinical sign in keratoconus

    Br J Ophthalmol

    (1975)
  • A.J. Bron et al.

    Stromal loss in keratoconus

    Trans Ophthalmol Soc UK

    (1978)
  • L.A. Brunsting et al.

    Occurrence of cataracts and keratoconus with atopic dermatitis

    Arch Dermatol

    (1955)
  • T.H. Butler

    Keratoconus posticus

    Tr Ophthalmol Soc UK

    (1930)
  • M Cafli

    Histopathology of keratoconus

    Annali Di Ottalmologia E Clinica Oculista

    (1966)
  • D.J. Cannon et al.

    Collagen crosslinking in keratoconus

    Invest Ophthalmol Vis Sci

    (1978)
  • Cited by (0)

    1

    Dr. Feder is currently an Associate, Northwestern Medical School, Chicago, Illinois.

    2

    Dr. Belin was a Heed Fellow at the University of Iowa and is currently and Assistant Professor of Ophthalmology, George Washington University School of Medicine, Washington, D.C.

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