Perspectives on massive osteolysis: Report of a case and review of the literature

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Abstract

Massive osteolysis is a rare, chronic disease characterized by the progressive dissolution of contiguous osseous structures. There is no regeneration following the osteolysis. Pathologic fracture often leads to its discovery. The etiology and pathophysiology of the disease remain obscure. Chemo- and radiotherapeutic attempts at arresting the osteolytic process are generally unsuccessful. Bone grafting has proved disappointing, as the graft usually undergoes osteolysis. A new case of facial bone involvement in a 13-year-old boy is presented. The literature is reviewed, and the clinical experience gained from treating the disease is discussed.

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    Chief Resident, Tufts Advanced Education Program.

    ∗∗

    Professor and Chairman and Associate Dean.

    ∗∗∗

    Professor of Radiology, Tufts Medical School; Senior Radiologist at Tufts New England Medical Center Hospital, Boston, Mass.

    ∗∗∗∗

    Private practice of oral surgery, Freehold, N.J.

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