Cardiac surgery and cold-reactive proteins

doi:10.1016/0003-4975(95)00501-B

The Annals of Thoracic Surgery

Volume 60, Issue 4, October 1995, Pages 1143-1150

https://doi.org/10.1016/0003-4975(95)00501-B Get rights and content

Cold agglutinins are commonly found in sera of healthy persons. They rarely become clinically apparent due to their activity at low temperatures. In these patients, cardiovascular operations requiring hypothermia can result in complications such as hemolysis, renal failure, and myocardial damage and can cause unexpected morbidity and mortality. The literature on cold-reactive proteins is reviewed, and methods of diagnosis and management related to cardiac surgery are suggested. Ideally all patients should be routinely tested preoperatively for the antibodies, and appropriate changes in cardiopulmonary bypass and myocardial management plans should be made in positive patients. Preoperative plasmapheresis may be a useful adjunct, especially in patients requiring operation under profound hypothermia and circulatory arrest. Currently, warm heart surgery appears to be the most expedient method. Unexpected detection of agglutination during operation or hemolysis after operation requires a specific treatment plan.

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Cardiac surgery and cold-reactive proteins

Ann Thorac Surg

Ann Thorac Surg

Surg Clin North Am

J Thorac Cardiovasc Surg

Ann Thorac Surg

Ann Thorac Surg

J Thorac Cardiovasc Surg

Ann Thorac Surg

J Thorac Cardiovasc Surg

J Cardiothorac Vasc Anesth

Chest

Ann Thorac Surg

Am J Med

Blood

Cold antibody and persistent intravascular hemolysis after surgery under hypothermia

Transfusion

Surgical hypothermia in a patient with a cold agglutinin: management by plasma exchange

Transfusion

Cold agglutinins: cause for concern?

Anaesthesia

Management of patients with cold agglutinins who require open heart surgery

Can J Surg

Successful cardiac bypass surgery in the presence of a potent cold agglutinin without plasma exchange

Transfusion

Cold agglutinins and deep hypothermia

Anaesthesia

Cardiac surgery in patients with cold autoimmune diseases

Anesth Analg

Cardiopulmonary bypass and myocardial protection: management problems in cardiac surgical patients with cold autoimmune disease

Anesth Analg

Use of a total wash-out method in an open heart operation

Ann Thorac Surg