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Treatment of CNS dissemination in systemic lymphoma

  • Imagers in Neuron-Oncology Clinical-Patient Studies
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Summary

The frequency of central nervous system (CNS) dissemination in non-Hodgkin’s lymphoma (NHL) varies and is dependent on NHL histology. More than 50% of patients with CNS involvement have advanced and progressive systemic disease. While CNS involvement at initial diagnosis may be treated curatively, treatment of CNS involvement in systemic relapsing or refractory lymphoma is challenging and most often palliative. Due to a paucity of randomized trials, treatment of lymphomatous metastases is not standardized. Nonetheless, treatment of LM entails administration of both CNS-directed and systemic chemotherapy that often includes high-dose chemotherapy regimens with stem cell support.

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Acknowledgement

We thank Michael Pfreundschuh for kindly reviewing the manuscript.

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Authors and Affiliations

  1. Internal Medicine I, University Saarland, Homburg, Germany

    B. Gleissner

  2. Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    M. Chamberlain

  3. Medical Clinic I, University Hospital of the Saarland, Kirrberger Strasse, 66421, Homburg, Germany

    B. Gleissner

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  1. B. Gleissner
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Correspondence to B. Gleissner.

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Gleissner and Chamberlain contributed equally.

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Gleissner, B., Chamberlain, M. Treatment of CNS dissemination in systemic lymphoma. J Neurooncol 84, 107–117 (2007). https://doi.org/10.1007/s11060-007-9353-z

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