Skip to main content

Advertisement

Log in

Gatifloxacin-induced severe hyperglycaemia and ketoacidosis in a non-diabetic renal transplant recipient

  • Case Report
  • Published:
Clinical and Experimental Nephrology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Gatifloxacin has been reported to cause dysglycaemia, especially in the elderly and in diabetics. In this communication, we describe a case of a non-diabetic renal transplant recipient who came to us in a state of diabetic ketoacidosis following the use of gatifloxacin for a urinary tract infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Biggs WS. Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients. J Am Board Fam Pract. 2003;16(5):455–7.

    Article  PubMed  Google Scholar 

  2. Kendall C, Wooltorton E. People with diabetes should avoid antibiotic gatifloxacin. CMAJ. 2006;174(8):1089–90.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Park-Wyllie LY, Juurlink DN, Kopp A, Shah BR, Stukel TA, Stumpo C, et al. Outpatient gatifloxacin therapy and dysglycemia in older adults. N Engl J Med. 2006;354(13):1352–61.

    Article  CAS  PubMed  Google Scholar 

  4. Ovartlarnporn M, Jongjaroenprasert W. Advancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients. J Med Assoc Thai. 2007;90(3):569–73.

    PubMed  Google Scholar 

  5. Yip C, Lee AJ. Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature. Clin Ther. 2006;28(11):1857–66.

    Article  CAS  PubMed  Google Scholar 

  6. Blommel AL, Lutes RA. Severe hyperglycemia during renally adjusted gatifloxacin therapy. Ann Pharmacother. 2005;39(7–8):1349–52.

    Article  PubMed  Google Scholar 

  7. Saraya A, Yokokura M, Gonoi T, Seino S. Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K + channels. Eur J Pharmacol. 2004;497:111–7.

    Article  CAS  PubMed  Google Scholar 

  8. Ishiwata Y, Sanada Y, Yasuhara M. Effects of gatifloxacin on serum glucose concentration in normal and diabetic rats. Biol Pharm Bull. 2006;29(3):527–31.

    Article  CAS  PubMed  Google Scholar 

  9. Grasela DM. Clinical pharmacology of gatifloxacin, a new fluoroquinolone. Clin Infect Dis. 2000;Suppl 2:S51–8.

    Article  Google Scholar 

  10. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30(2):239–45.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sanjay K. Agarwal.

About this article

Cite this article

Khaira, A., Gupta, A., Tandon, N. et al. Gatifloxacin-induced severe hyperglycaemia and ketoacidosis in a non-diabetic renal transplant recipient. Clin Exp Nephrol 13, 89–91 (2009). https://doi.org/10.1007/s10157-008-0072-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10157-008-0072-3

Keywords

Navigation