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ASO titer or not? When to use streptococcal serology: a guide for clinicians

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European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

Clinicians frequently request serologic tests to provide evidence of prior infection by Streptococcus pyogenes, especially when suspecting a diagnosis of acute rheumatic fever or post-streptococcal glomerulonephritis. However, the interpretation of these tests is difficult and should take account of the clinical features, epidemiological setting, and pre-test probability, as well as the specific aspects of the assay. This review details the characteristics of streptococcal serologic assays and provides recommendations for their use and interpretation.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Oxford University, Oxford, UK

    T. Parks

  2. Murdoch Childrens Research Institute, Parkville, Australia

    P. R. Smeesters, N. Curtis & A. C. Steer

  3. Department of Paediatrics, University of Melbourne, Second Floor, Royal Children’s Hospital Melbourne, Flemington Road, Parkville, VIC, 3052, Australia

    N. Curtis & A. C. Steer

  4. Infectious Diseases Unit, Royal Children’s Hospital Melbourne, Parkville, Australia

    N. Curtis & A. C. Steer

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  1. T. Parks
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  2. P. R. Smeesters
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  3. N. Curtis
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  4. A. C. Steer
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Correspondence to A. C. Steer.

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Parks, T., Smeesters, P.R., Curtis, N. et al. ASO titer or not? When to use streptococcal serology: a guide for clinicians. Eur J Clin Microbiol Infect Dis 34, 845–849 (2015). https://doi.org/10.1007/s10096-014-2303-8

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  • DOI: https://doi.org/10.1007/s10096-014-2303-8

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